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Interaction between Copper Oxide Nanoparticles and Amino Acids: Influence on the Antibacterial Activity

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DAIS—Department of Environmental Sciences, Informatics and Statistics, University Ca’ Foscari of Venice, Via Torino 155, 30172 Venice Mestre, Italy
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DMSN—Department of Molecular Sciences and Nanosystems, University Ca’ Foscari of Venice, Via Torino 155/b, 30172 Venice Mestre, Italy
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ECLT Lab—European Centre for Living Technology, University Ca’ Foscari of Venice, Via Torino 155/b, 30172 Venice Mestre, Italy
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Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(5), 792; https://doi.org/10.3390/nano9050792
Received: 9 May 2019 / Accepted: 20 May 2019 / Published: 23 May 2019
The increasing concern about antibiotic-resistance has led to the search for alternative antimicrobial agents. In this effort, different metal oxide nanomaterials are currently under investigation, in order to assess their effectiveness, safety and mode of action. This study focused on CuO nanoparticles (CuO NPs) and was aimed at evaluating how the properties and the antimicrobial activity of these nanomaterials may be affected by the interaction with ligands present in biological and environmental media. Ligands can attach to the surface of particles and/or contribute to their dissolution through ligand-assisted ion release and the formation of complexes with copper ions. Eight natural amino acids (L-Arg, L-Asp, L-Glu, L-Cys, L-Val, L-Leu, L-Phe, L-Tyr) were chosen as model molecules to investigate these interactions and the toxicity of the obtained materials against the Gram-positive bacterium Staphylococcus epidermidis ATCC 35984. A different behavior from pristine CuO NPs was observed, depending on the aminoacidic side chain. These results were supported by physico-chemical and colloidal characterization carried out by means of Fourier-Transform Infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Thermo-Gravimetric Analysis (TGA), Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and light scattering techniques (Dynamic Light Scattering (DLS), Electrophoretic Light Scattering (ELS) and Centrifugal Separation Analysis (CSA). View Full-Text
Keywords: copper oxide nanoparticles; amino acids; antimicrobial activity copper oxide nanoparticles; amino acids; antimicrobial activity
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MDPI and ACS Style

Badetti, E.; Calgaro, L.; Falchi, L.; Bonetto, A.; Bettiol, C.; Leonetti, B.; Ambrosi, E.; Zendri, E.; Marcomini, A. Interaction between Copper Oxide Nanoparticles and Amino Acids: Influence on the Antibacterial Activity. Nanomaterials 2019, 9, 792.

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