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Chinese White Wax Solid Lipid Nanoparticles as a Novel Nanocarrier of Curcumin for Inhibiting the Formation of Staphylococcus aureus Biofilms

College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China
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Nanomaterials 2019, 9(5), 763; https://doi.org/10.3390/nano9050763
Received: 29 March 2019 / Revised: 30 April 2019 / Accepted: 9 May 2019 / Published: 17 May 2019
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Abstract

Chinese white wax solid lipid nanoparticles (cwSLNs) were prepared by high shear homogenization and ultrasound methods. Using an optimized formula, spherical cwSLNs with an average particle size of 401.9 ± 21.3 nm were obtained. The cwSLNs showed high entrapment efficiency, approximately 84.6%, for loading curcumin. The curcumin loaded cwSLNs (Cur-cwSLNs) exhibited sustained drug release properties. Notably, Cur-cwSLNs had a higher drug release rate at pH 4.5 than at pH 7.4, which suggested their applicability in an acidic environment. Cur-cwSLNs were able to inhibit the growth of Staphylococcus aureus and were more effective at reducing the biofilms produced by this bacterium compared to free curcumin. This study confirmed that cwSLNs may be novel carriers for increasing the bioavailability of curcumin with the potential to inhibit the formation of S. aureus biofilms. View Full-Text
Keywords: Chinese white wax; solid lipid nanoparticles; curcumin; biofilms; Staphylococcus aureus Chinese white wax; solid lipid nanoparticles; curcumin; biofilms; Staphylococcus aureus
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Luan, L.; Chi, Z.; Liu, C. Chinese White Wax Solid Lipid Nanoparticles as a Novel Nanocarrier of Curcumin for Inhibiting the Formation of Staphylococcus aureus Biofilms. Nanomaterials 2019, 9, 763.

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