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Open AccessArticle

Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin

Research Institute of Wood Industry, Chinese Academy of Forestry, Xiangshan Road, Beijing 100089, China
College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(2), 188;
Received: 30 December 2018 / Revised: 20 January 2019 / Accepted: 28 January 2019 / Published: 2 February 2019
Due to their exceptional absorption capacity, biodegradability, and non-toxicity, nanoparticles (NPs) from lignin have emerged as vehicles for inorganic particles and drug molecules. However, the method for preparing targeted lignin particles is still complex and lacks sufficient research. Herein, a succinct strategy was proposed for the preparation of targeted lignin-based drug delivery NPs to load Doxorubicin Hydrochloride (DOX). The lignin hollow NPs (LHNPs) were used as a platform for the preparation of targeted delivery material by incorporating magnetic NPs and folic acid (FA) via layer-by-layer self-assembling. The results showed that the surface of LHNPs was covered uniformly by Fe3O4 NPs and grafted with folic acid. The folic-magnetic-functionalized lignin hollow NPs (FA-MLHNPs) could respond to magnetic field and folic acid receptors. In addition, the targeting performance of the FA-MLHNPs increased the cellular uptake of NPs in the case of HeLa cells. This research not only supported the modified NPs platform as a highly efficient nano-delivery method but also provided a facile approach to utilize renewable lignin biomaterials. View Full-Text
Keywords: lignin; nanoparticles; targeted materials; drug delivery lignin; nanoparticles; targeted materials; drug delivery
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MDPI and ACS Style

Zhou, Y.; Han, Y.; Li, G.; Yang, S.; Xiong, F.; Chu, F. Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin. Nanomaterials 2019, 9, 188.

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