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Open AccessArticle

Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin

1
Research Institute of Wood Industry, Chinese Academy of Forestry, Xiangshan Road, Beijing 100089, China
2
College of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China
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Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(2), 188; https://doi.org/10.3390/nano9020188
Received: 30 December 2018 / Revised: 20 January 2019 / Accepted: 28 January 2019 / Published: 2 February 2019
Due to their exceptional absorption capacity, biodegradability, and non-toxicity, nanoparticles (NPs) from lignin have emerged as vehicles for inorganic particles and drug molecules. However, the method for preparing targeted lignin particles is still complex and lacks sufficient research. Herein, a succinct strategy was proposed for the preparation of targeted lignin-based drug delivery NPs to load Doxorubicin Hydrochloride (DOX). The lignin hollow NPs (LHNPs) were used as a platform for the preparation of targeted delivery material by incorporating magnetic NPs and folic acid (FA) via layer-by-layer self-assembling. The results showed that the surface of LHNPs was covered uniformly by Fe3O4 NPs and grafted with folic acid. The folic-magnetic-functionalized lignin hollow NPs (FA-MLHNPs) could respond to magnetic field and folic acid receptors. In addition, the targeting performance of the FA-MLHNPs increased the cellular uptake of NPs in the case of HeLa cells. This research not only supported the modified NPs platform as a highly efficient nano-delivery method but also provided a facile approach to utilize renewable lignin biomaterials. View Full-Text
Keywords: lignin; nanoparticles; targeted materials; drug delivery lignin; nanoparticles; targeted materials; drug delivery
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MDPI and ACS Style

Zhou, Y.; Han, Y.; Li, G.; Yang, S.; Xiong, F.; Chu, F. Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin. Nanomaterials 2019, 9, 188.

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