Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin
AbstractDue to their exceptional absorption capacity, biodegradability, and non-toxicity, nanoparticles (NPs) from lignin have emerged as vehicles for inorganic particles and drug molecules. However, the method for preparing targeted lignin particles is still complex and lacks sufficient research. Herein, a succinct strategy was proposed for the preparation of targeted lignin-based drug delivery NPs to load Doxorubicin Hydrochloride (DOX). The lignin hollow NPs (LHNPs) were used as a platform for the preparation of targeted delivery material by incorporating magnetic NPs and folic acid (FA) via layer-by-layer self-assembling. The results showed that the surface of LHNPs was covered uniformly by Fe3O4 NPs and grafted with folic acid. The folic-magnetic-functionalized lignin hollow NPs (FA-MLHNPs) could respond to magnetic field and folic acid receptors. In addition, the targeting performance of the FA-MLHNPs increased the cellular uptake of NPs in the case of HeLa cells. This research not only supported the modified NPs platform as a highly efficient nano-delivery method but also provided a facile approach to utilize renewable lignin biomaterials. View Full-Text
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Zhou, Y.; Han, Y.; Li, G.; Yang, S.; Xiong, F.; Chu, F. Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin. Nanomaterials 2019, 9, 188.
Zhou Y, Han Y, Li G, Yang S, Xiong F, Chu F. Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin. Nanomaterials. 2019; 9(2):188.Chicago/Turabian Style
Zhou, Yu; Han, Yanming; Li, Gaiyun; Yang, Sheng; Xiong, Fuquan; Chu, Fuxiang. 2019. "Preparation of Targeted Lignin–Based Hollow Nanoparticles for the Delivery of Doxorubicin." Nanomaterials 9, no. 2: 188.
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