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Open AccessArticle

Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI)

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Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Campus de la UAB, 08193 Bellaterra (Barcelona), Spain
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Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, UK
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Servei de Ressonància Magnètica Nuclear, Universitat Autònoma de Barcelona, Campus UAB, 08193 Bellaterra (Barcelona), Spain
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Centro de Investigación Biomédica en Red-Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Universitat Autònoma de Barcelona, Campus UAB, 08193 Bellaterra (Barcelona), Spain
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Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and the Barcelona Institute of Science and Technology, Campus UAB, 08193 Bellaterra (Barcelona), Spain
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(10), 1364; https://doi.org/10.3390/nano9101364
Received: 6 August 2019 / Revised: 17 September 2019 / Accepted: 18 September 2019 / Published: 24 September 2019
Magnetic resonance imaging (MRI) is a useful tool for disease diagnosis and treatment monitoring. Superparamagnetic iron oxide nanoparticles (SPION) show good performance as transverse relaxation (T2) contrast agents, thus facilitating the interpretation of the acquired images. Attachment of SPION onto nanocarriers prevents their agglomeration, improving the circulation time and efficiency. Graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (RGO), are appealing nanocarriers since they have both high surface area and functional moieties that make them ideal substrates for the attachment of nanoparticles. We have employed a fast, simple and environmentally friendly microwave-assisted approach for the synthesis of SPION-RGO hybrids. Different iron precursor/GO ratios were used leading to SPION, with a median diameter of 7.1 nm, homogeneously distributed along the RGO surface. Good relaxivity (r2*) values were obtained in MRI studies and no significant toxicity was detected within in vitro tests following GL261 glioma and J774 macrophage-like cells for 24 h with SPION-RGO, demonstrating the applicability of the hybrids as T2-weighted MRI contrast agents. View Full-Text
Keywords: contrast agents; biomedical imaging; ultrasmall superparamagnetic iron oxide nanoparticles contrast agents; biomedical imaging; ultrasmall superparamagnetic iron oxide nanoparticles
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MDPI and ACS Style

Llenas, M.; Sandoval, S.; Costa, P.M.; Oró-Solé, J.; Lope-Piedrafita, S.; Ballesteros, B.; Al-Jamal, K.T.; Tobias, G. Microwave-Assisted Synthesis of SPION-Reduced Graphene Oxide Hybrids for Magnetic Resonance Imaging (MRI). Nanomaterials 2019, 9, 1364.

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