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Nanomaterials 2018, 8(7), 519;

Applications of Nanosheets in Frontier Cellular Research

1,3,* , 1,3
Micro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka-city, Kanagawa 259-1292, Japan
Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Department of Mechanical Engineering, Tokai University, 4-1-1 Kitakaname, Hiratsuka-city, Kanagawa 259-1292, Japan
Division of Biomedical Engineering, Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 28 May 2018 / Revised: 5 July 2018 / Accepted: 10 July 2018 / Published: 12 July 2018
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Several types of nanosheets, such as graphene oxide (GO) nanosheet, molybdenum disulfide (MoS2) and poly(l-lactic acid) (PLLA) nanosheets, have been developed and applied in vitro in cellular research over the past decade. Scientists have used nanosheet properties, such as ease of modification and flexibility, to develop new cell/protein sensing/imaging techniques and achieve regulation of specific cell functions. This review is divided into three main parts based on the application being examined: nanosheets as a substrate, nanosheets as a sensitive surface, and nanosheets in regenerative medicine. Furthermore, the applications of nanosheets are discussed, with two subsections in each section, based on their effects on cells and molecules. Finally, the application prospects of nanosheets in cellular research are summarized. View Full-Text
Keywords: nanosheet; cell adhesion; drug delivery; cell capturing; regenerative medicine nanosheet; cell adhesion; drug delivery; cell capturing; regenerative medicine

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Huang, W.; Sunami, Y.; Kimura, H.; Zhang, S. Applications of Nanosheets in Frontier Cellular Research. Nanomaterials 2018, 8, 519.

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