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Open AccessReview

Applications of Nanosheets in Frontier Cellular Research

by Wenjing Huang 1,2,†, Yuta Sunami 1,3,*, Hiroshi Kimura 1,3 and Sheng Zhang 1,4,*,†
1
Micro/Nano Technology Center, Tokai University, 4-1-1 Kitakaname, Hiratsuka-city, Kanagawa 259-1292, Japan
2
Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
3
Department of Mechanical Engineering, Tokai University, 4-1-1 Kitakaname, Hiratsuka-city, Kanagawa 259-1292, Japan
4
Division of Biomedical Engineering, Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2018, 8(7), 519; https://doi.org/10.3390/nano8070519
Received: 28 May 2018 / Revised: 5 July 2018 / Accepted: 10 July 2018 / Published: 12 July 2018
Several types of nanosheets, such as graphene oxide (GO) nanosheet, molybdenum disulfide (MoS2) and poly(l-lactic acid) (PLLA) nanosheets, have been developed and applied in vitro in cellular research over the past decade. Scientists have used nanosheet properties, such as ease of modification and flexibility, to develop new cell/protein sensing/imaging techniques and achieve regulation of specific cell functions. This review is divided into three main parts based on the application being examined: nanosheets as a substrate, nanosheets as a sensitive surface, and nanosheets in regenerative medicine. Furthermore, the applications of nanosheets are discussed, with two subsections in each section, based on their effects on cells and molecules. Finally, the application prospects of nanosheets in cellular research are summarized. View Full-Text
Keywords: nanosheet; cell adhesion; drug delivery; cell capturing; regenerative medicine nanosheet; cell adhesion; drug delivery; cell capturing; regenerative medicine
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Huang, W.; Sunami, Y.; Kimura, H.; Zhang, S. Applications of Nanosheets in Frontier Cellular Research. Nanomaterials 2018, 8, 519.

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