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Nanomaterials 2018, 8(4), 184; https://doi.org/10.3390/nano8040184

Electrospun Blank Nanocoating for Improved Sustained Release Profiles from Medicated Gliadin Nanofibers

School of Material Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
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Received: 25 February 2018 / Revised: 17 March 2018 / Accepted: 18 March 2018 / Published: 22 March 2018
(This article belongs to the Special Issue Functional Nanomaterials by Electrospinning)
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Abstract

Nanomaterials providing sustained release profiles are highly desired for efficacious drug delivery. Advanced nanotechnologies are useful tools for creating elaborate nanostructure-based nanomaterials to achieve the designed functional performances. In this research, a modified coaxial electrospinning was explored to fabricate a novel core-sheath nanostructure (nanofibers F2), in which a sheath drug-free gliadin layer was successfully coated on the core ketoprofen (KET)-gliadin nanocomposite. A monolithic nanocomposite (nanofibers F1) that was generated through traditional blending electrospinning of core fluid was utilized as a control. Scanning electron microscopy demonstrated that both nanofibers F1 and F2 were linear. Transmission electron microscopy verified that nanofibers F2 featured a clear core-sheath nanostructure with a thin sheath layer about 25 nm, whereas their cores and nanofibers F1 were homogeneous KET-gliadin nanocomposites. X-ray diffraction patterns verified that, as a result of fine compatibility, KET was dispersed in gliadin in an amorphous state. In vitro dissolution tests demonstrated that the thin blank nanocoating in nanofibers F2 significantly modified drug release kinetics from a traditional exponential equation of nanofibers F1 to a zero-order controlled release model, linearly freeing 95.7 ± 4.7% of the loaded cargoes over a time period of 16 h. View Full-Text
Keywords: medicated nanofiber; nanocoating; coaxial electrospinning; structural nanocomposite; sustained release; poorly water-soluble drug medicated nanofiber; nanocoating; coaxial electrospinning; structural nanocomposite; sustained release; poorly water-soluble drug
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Liu, X.; Shao, W.; Luo, M.; Bian, J.; Yu, D.-G. Electrospun Blank Nanocoating for Improved Sustained Release Profiles from Medicated Gliadin Nanofibers. Nanomaterials 2018, 8, 184.

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