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Open AccessArticle

Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy

1
NanoBioMedical Centre, Adam Mickiewicz University in Poznan, Umultowska 85, PL-61614 Poznan, Poland
2
Faculty of Chemical Technology, Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, PL-60965 Poznan, Poland
*
Authors to whom correspondence should be addressed.
Nanomaterials 2018, 8(3), 170; https://doi.org/10.3390/nano8030170
Received: 23 January 2018 / Revised: 7 March 2018 / Accepted: 10 March 2018 / Published: 16 March 2018
Polydopamine (PDA)-coated magnetic nanoparticles functionalized with mono-6-thio-β-cyclodextrin (SH-βCD) were obtained and characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), Nuclear and Magnetic Resonance Imaging (NMR and MRI), and doxorubicin (DOXO)-loading experiments. The liver cancer cellular internalization of DOXO-loaded nanoparticles was investigated by confocal imaging microscopy. Synthesized nanomaterials bearing a chemotherapeutic drug and a layer of polydopamine capable of absorbing near-infrared light show high performance in the combined chemo- and photothermal therapy (CT-PTT) of liver cancer due to the synergistic effect of both modalities as demonstrated in vitro. Moreover, our material exhibits improved T2 contrast properties, which have been verified using Carr-Purcell-Meiboom-Gill pulse sequence and MRI Spin-Echo imaging of the nanoparticles dispersed in the agarose gel phantoms. Therefore, the presented results cast new light on the preparation of polydopamine-based magnetic theranostic nanomaterials, as well as on the proper methodology for investigation of magnetic nanoparticles in high field MRI experiments. The prepared material is a robust theranostic nanoasystem with great potential in nanomedicine. View Full-Text
Keywords: magnetic nanoparticles; polydopamine; theranostic; MRI; nanomedicine magnetic nanoparticles; polydopamine; theranostic; MRI; nanomedicine
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Mrówczyński, R.; Jędrzak, A.; Szutkowski, K.; Grześkowiak, B.F.; Coy, E.; Markiewicz, R.; Jesionowski, T.; Jurga, S. Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy. Nanomaterials 2018, 8, 170.

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