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Nanomaterials 2018, 8(10), 857; https://doi.org/10.3390/nano8100857

Antagonistic Effect of Azoxystrobin Poly (Lactic Acid) Microspheres with Controllable Particle Size on Colletotrichum higginsianum Sacc

1
Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing, 100081, China
2
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 6 September 2018 / Revised: 6 October 2018 / Accepted: 12 October 2018 / Published: 19 October 2018
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Abstract

Size-controlled azoxystrobin-poly (lactic acid) microspheres (MS) were prepared by an oil/water emulsion solvent evaporation approach. The hydrated mean particle sizes of the MS1, MS2, and MS3 aqueous dispersions were 130.9 nm, 353.4 nm, and 3078.0 nm, respectively. The drug loading and encapsulation efficiency of the azoxystrobin microspheres had a positive relationship with particle size. However, the release rate and percentage of cumulative release were inversely related to particle size. The smaller-sized microspheres had a greater potential to access the target mitochondria. As a result, the more severe oxidative damage of Colletotrichum higginsianum Sacc and higher antagonistic activity were induced by the smaller particle size of azoxystrobin microspheres. The 50% lethal concentrations against Colletotrichum higginsianum Sacc of MS1, MS2, and MS3 were 2.0386 μg/mL, 12.7246 μg/mL, and 21.2905 μg/mL, respectively. These findings reveal that particle size is a critical factor in increasing the bioavailability of insoluble fungicide. View Full-Text
Keywords: azoxystrobin; microsphere; Colletotrichum higginsianum Sacc; oxidative damage; antagonistic activity azoxystrobin; microsphere; Colletotrichum higginsianum Sacc; oxidative damage; antagonistic activity
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Yao, J.; Cui, B.; Zhao, X.; Zhi, H.; Zeng, Z.; Wang, Y.; Sun, C.; Liu, G.; Gao, J.; Cui, H. Antagonistic Effect of Azoxystrobin Poly (Lactic Acid) Microspheres with Controllable Particle Size on Colletotrichum higginsianum Sacc. Nanomaterials 2018, 8, 857.

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