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Biosynthesis of Copper Oxide (CuO) Nanowires and Their Use for the Electrochemical Sensing of Dopamine
Open AccessArticle

Copper Oxide Nanoparticles Cause a Dose-Dependent Toxicity via Inducing Reactive Oxygen Species in Drosophila

1
Daegu International School, 22 Palgongro, 50-Gil, Donggu, Daegu 701-170, Korea
2
Nanomedicine Research Unit, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Nanomaterials 2018, 8(10), 824; https://doi.org/10.3390/nano8100824
Received: 27 September 2018 / Revised: 6 October 2018 / Accepted: 7 October 2018 / Published: 12 October 2018
Copper oxide nanoparticles (CuONPs) have attracted considerable attention, because of their biocide potential and capability for optical imaging, however CuONPs were shown to be highly toxic in various experimental model systems. In this study, mechanism underlying CuONP-induced toxicity was investigated using Drosophila as an in vivo model. Upon oral route of administration, CuONPs accumulated in the body, and caused a dose-dependent decrease in egg-to-adult survivorship and a delay in development. In particular, transmission electron microscopy analysis revealed CuONPs were detected inside the intestinal epithelial cells and lumen. A drastic increase in apoptosis and reactive oxygen species was also observed in the gut exposed to CuONPs. Importantly, we found that inhibition of the transcription factor Nrf2 further enhances the toxicity caused by CuONPs. These observations suggest that CuONPs disrupt the gut homeostasis and that oxidative stress serves as one of the primary causes of CuONP-induced toxicity in Drosophila. View Full-Text
Keywords: copper oxide nanoparticle; cytotoxicity; reactive oxygen species; Nrf2; Drosophila melanogaster copper oxide nanoparticle; cytotoxicity; reactive oxygen species; Nrf2; Drosophila melanogaster
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MDPI and ACS Style

Baeg, E.; Sooklert, K.; Sereemaspun, A. Copper Oxide Nanoparticles Cause a Dose-Dependent Toxicity via Inducing Reactive Oxygen Species in Drosophila. Nanomaterials 2018, 8, 824.

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