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Nanomaterials 2018, 8(10), 812; https://doi.org/10.3390/nano8100812

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

1
Remote Controlled Theranostic Systems Lab, Saratov State University, Saratov 410012, Russia
2
Scientific Research Institute of Fundamental and Clinical Uronephrology, Saratov Medical State University, Saratov 410000, Russia
3
Biophotonics Laboratory, Skoltech Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, Moscow 121205, Russia
4
Laboratory of Pharmacokinetics and Targeted Drug Delivery, Medicine Institute, National Research Ogarev Mordovia State University, Saransk 430005, Russia
5
School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK
*
Author to whom correspondence should be addressed.
Received: 27 September 2018 / Revised: 6 October 2018 / Accepted: 7 October 2018 / Published: 10 October 2018
(This article belongs to the Special Issue Nanocolloids for Nanomedicine and Drug Delivery)
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Abstract

Multilayer capsules of 4 microns in size made of biodegradable polymers and iron oxide magnetite nanoparticles have been injected intravenously into rats. The time-dependent microcapsule distribution in organs was investigated in vivo by magnetic resonance imaging (MRI) and ex vivo by histological examination (HE), atomic absorption spectroscopy (AAS) and electron spin resonance (ESR), as these methods provide information at different stages of microcapsule degradation. The following organs were collected: Kidney, liver, lung, and spleen through 15 min, 1 h, 4 h, 24 h, 14 days, and 30 days after intravenous injections (IVIs) of microcapsules in a saline buffer at a dosage of 2.5 × 109 capsule per kg. The IVI of microcapsules resulted in reversible morphological changes in most of the examined inner organs (kidney, heart, liver, and spleen). The capsules lost their integrity due to degradation over 24 h, and some traces of iron oxide nanoparticles were seen at 7 days in spleen and liver structure. The morphological structure of the tissues was completely restored one month after IVI of microcapsules. Comprehensive analysis of the biodistribution and degradation of entire capsules and magnetite nanoparticles as their components gave us grounds to recommend these composite microcapsules as useful and safe tools for drug delivery applications. View Full-Text
Keywords: polymer microcapsules; magnetite nanoparticles; biodistribution; magnetic resonance imaging; electron spin resonance spectroscopy; histological examination; atomic absorption spectroscopy; intravenous injections polymer microcapsules; magnetite nanoparticles; biodistribution; magnetic resonance imaging; electron spin resonance spectroscopy; histological examination; atomic absorption spectroscopy; intravenous injections
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Navolokin, N.A.; German, S.V.; Bucharskaya, A.B.; Godage, O.S.; Zuev, V.V.; Maslyakova, G.N.; Pyataev, N.A.; Zamyshliaev, P.S.; Zharkov, M.N.; Terentyuk, G.S.; Gorin, D.A.; Sukhorukov, G.B. Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study. Nanomaterials 2018, 8, 812.

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