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Chiral Nanotubes
Open AccessReview

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

1
Chirality Program, Biomedical Science, University of Canberra, Bruce, Australian Capital Territory (ACT) 2617, Australia
2
Collaborative Research in Bioactives and Biomarkers Group (CRIBB), University of Canberra, Bruce, Australian Capital Territory (ACT) 2617, Australia
3
Ecochemistry Laboratory, Institute for Applied Ecology, University of Canberra, Bruce, Australian Capital Territory (ACT) 2617, Australia
*
Author to whom correspondence should be addressed.
Nanomaterials 2017, 7(7), 186; https://doi.org/10.3390/nano7070186
Received: 13 June 2017 / Revised: 4 July 2017 / Accepted: 6 July 2017 / Published: 18 July 2017
(This article belongs to the Special Issue Frontiers in Chiral Nanomaterials)
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PDF [4015 KB, uploaded 18 July 2017]
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Abstract

Carbon nanotubes (CNTs) possess unique mechanical, physical, electrical and absorbability properties coupled with their nanometer dimensional scale that renders them extremely valuable for applications in many fields including nanotechnology and chromatographic separation. The aim of this review is to provide an updated overview about the applications of CNTs in chiral and achiral separations of pharmaceuticals, biologics and chemicals. Chiral single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) have been directly applied for the enantioseparation of pharmaceuticals and biologicals by using them as stationary or pseudostationary phases in chromatographic separation techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis (CE) and gas chromatography (GC). Achiral MWCNTs have been used for achiral separations as efficient sorbent objects in solid-phase extraction techniques of biochemicals and drugs. Achiral SWCNTs have been applied in achiral separation of biological samples. Achiral SWCNTs and MWCNTs have been also successfully used to separate achiral mixtures of pharmaceuticals and chemicals. Collectively, functionalized CNTs have been indirectly applied in separation science by enhancing the enantioseparation of different chiral selectors whereas non-functionalized CNTs have shown efficient capabilities for chiral separations by using techniques such as encapsulation or immobilization in polymer monolithic columns. View Full-Text
Keywords: carbon nanotubes; chiral separation; achiral separation; single-walled carbon nanotubes; multi-walled carbon nanotubes carbon nanotubes; chiral separation; achiral separation; single-walled carbon nanotubes; multi-walled carbon nanotubes
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Hemasa, A.L.; Naumovski, N.; Maher, W.A.; Ghanem, A. Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals. Nanomaterials 2017, 7, 186.

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