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Nanomaterials 2017, 7(7), 162; https://doi.org/10.3390/nano7070162

Biological Fate of Fe3O4 Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry

1
Institut Charles Gerhardt de Montpellier (ICGM), Montpellier University-Campus Triolet (CNRS UMR 5253/UM/ENSCM), Place Eugène Bataillon, CEDEX 5, 34095 Montpellier, France
2
NanoMedSyn, 15 Avenue Charles Flahault, 34093 Montpellier, France
3
IBMM, CNRS UMR 5247/UM/ENSCM Faculty of de Pharmaceutical Sciences of Montpellier 15, Avenue Charles Flahault, CEDEX 05, 34093 Montpellier, France
4
Center of Structural Biochemistry (CNRS UMR 5048/INSERM U 1054/UM), 29 rue de Navacelles, 34090 Montpellier, France
5
Aix-Marseille Université, CNRS, IRD, Coll de France, CEREGE, 13001 Aix en Provence, France
6
Université de Nîmes, Rue Georges Salan, Nîmes 30000, France
*
Authors to whom correspondence should be addressed.
Received: 4 June 2017 / Revised: 19 June 2017 / Accepted: 23 June 2017 / Published: 30 June 2017
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Abstract

The biological fate of nanoparticles (NPs) for biomedical applications is highly dependent of their size and charge, their aggregation state and their surface chemistry. The chemical composition of the NPs surface influences their stability in biological fluids, their interaction with proteins, and their attraction to the cell membranes. In this work, core-shell magnetic mesoporous silica nanoparticles (Fe3O4@MSN), that are considered as potential theranostic candidates, are coated with polyethylene glycol (PEG) or 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer. Their biological fate is studied in comparison to the native NPs. The physicochemical properties of these three types of NPs and their suspension behavior in different media are investigated. The attraction to a membrane model is also evaluated using a supported lipid bilayer. The surface composition of NPs strongly influences their dispersion in biological fluids mimics, protein binding and their interaction with cell membrane. While none of these types of NPs is found to be toxic on mice four days after intravenous injection of a dose of 40 mg kg−1 of NPs, their surface coating nature influences the in vivo biodistribution. Importantly, NP coated with DMPC exhibit a strong accumulation in liver and a very low accumulation in lung in comparison with nude or PEG ones. View Full-Text
Keywords: nanoparticles; surface coating; cell-membrane interactions; biodistribution; safety nanoparticles; surface coating; cell-membrane interactions; biodistribution; safety
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Rascol, E.; Daurat, M.; Da Silva, A.; Maynadier, M.; Dorandeu, C.; Charnay, C.; Garcia, M.; Lai-Kee-Him, J.; Bron, P.; Auffan, M.; Liu, W.; Angeletti, B.; Devoisselle, J.-M.; Guari, Y.; Gary-Bobo, M.; Chopineau, J. Biological Fate of Fe3O4 Core-Shell Mesoporous Silica Nanoparticles Depending on Particle Surface Chemistry. Nanomaterials 2017, 7, 162.

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