Next Article in Journal
Fabrication of Functional Polyurethane/Rare Earth Nanocomposite Membranes by Electrospinning and Its VOCs Absorption Capacity from Air
Next Article in Special Issue
Cytotoxicity of ZnO Nanowire Arrays on Excitable Cells
Previous Article in Journal
Effect of the Polymeric Stabilizer in the Aqueous Phase Fischer-Tropsch Synthesis Catalyzed by Colloidal Cobalt Nanocatalysts
Open AccessArticle

Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant

Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Gianni Ciofani
Nanomaterials 2017, 7(3), 59; https://doi.org/10.3390/nano7030059
Received: 16 January 2017 / Accepted: 5 March 2017 / Published: 8 March 2017
(This article belongs to the Special Issue Nanoparticle-Mediated Cell and Tissue Stimulation)
The application of graphene oxide (GO) as a potential vaccine adjuvant has recently attracted considerable attention. However, appropriate surface functionalization of GO is crucial to improve its biocompatibility and enhance its adjuvant activity. In this study, we developed a simple method to prepare chitosan (CS)-functionalized GO (GO-CS) and further investigated its potential as a nanoadjuvant. Compared with GO, GO-CS possessed considerably smaller size, positive surface charge, and better thermal stability. The functionalization of GO with CS was effective in decreasing the non-specific protein adsorption and improving its biocompatibility. Furthermore, GO-CS significantly activated RAW264.7 cells and stimulated more cytokines for mediating cellular immune response, which was mainly due to the synergistic immunostimulatory effect of both GO and CS. GO-CS exhibits strong potential as a safe nanoadjuvant for vaccines and immunotherapy. View Full-Text
Keywords: graphene oxide; chitosan; protein adsorption; cytokines; adjuvant graphene oxide; chitosan; protein adsorption; cytokines; adjuvant
Show Figures

Figure 1

MDPI and ACS Style

Yan, T.; Zhang, H.; Huang, D.; Feng, S.; Fujita, M.; Gao, X.-D. Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant. Nanomaterials 2017, 7, 59.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop