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Open AccessArticle

Evaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering

1
Laboratoire de BioMécanique et de BioIngénierie (BMBI) UMR CNRS 7388, Sorbonne Universités, Université de Technologie of Compiègne (UTC), 60200 Compiègne, France
2
Equipe de Recherche sur les Relations Matrice Extracellulaire Cellules (Errmece), Institut des Matériaux, Université de Cergy-Pontoise, 95000 Cergy-Pontoise, France
3
Laboratoire de Physicochimie des Polymères et des Interfaces (LPPI), Institut des Matériaux, Université de Cergy-Pontoise, 95000 Cergy-Pontoise, France
4
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
5
Department of Chemical Engineering, Northeastern University, 360 Huntington Avenue, Boston, MA 02215, USA
*
Authors to whom correspondence should be addressed.
Nanomaterials 2017, 7(12), 436; https://doi.org/10.3390/nano7120436
Received: 31 October 2017 / Revised: 30 November 2017 / Accepted: 5 December 2017 / Published: 10 December 2017
(This article belongs to the Special Issue Nanofibrous Scaffolds for Biomedical Application)
Interpenetrating polymer networks (IPNs) have gained great attention for a number of biomedical applications due to their improved properties compared to individual components alone. In this study, we investigated the capacity of newly-developed naturally-derived IPNs as potential biomaterials for tissue engineering. These IPNs combine the biologic properties of a fibrous fibrin network polymerized at the nanoscale and the mechanical stability of polyethylene oxide (PEO). First, we assessed their cytotoxicity in vitro on L929 fibroblasts. We further evaluated their biocompatibility ex vivo with a chick embryo organotypic culture model. Subcutaneous implantations of the matrices were subsequently conducted on nude mice to investigate their biocompatibility in vivo. Our preliminary data highlighted that our biomaterials were non-cytotoxic (viability above 90%). The organotypic culture showed that the IPN matrices induced higher cell adhesion (across all the explanted organ tissues) and migration (skin, intestine) than the control groups, suggesting the advantages of using a biomimetic, yet mechanically-reinforced IPN-based matrix. We observed no major inflammatory response up to 12 weeks post implantation. All together, these data suggest that these fibrin-based IPNs are promising biomaterials for tissue engineering. View Full-Text
Keywords: interpenetrating polymer networks; fibrin; polyethylene oxide; serum albumin; fibrous hydrogel; biocompatibility; organotypic culture; tissue engineering; biomaterials interpenetrating polymer networks; fibrin; polyethylene oxide; serum albumin; fibrous hydrogel; biocompatibility; organotypic culture; tissue engineering; biomaterials
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Gsib, O.; Duval, J.-L.; Goczkowski, M.; Deneufchatel, M.; Fichet, O.; Larreta-Garde, V.; Bencherif, S.A.; Egles, C. Evaluation of Fibrin-Based Interpenetrating Polymer Networks as Potential Biomaterials for Tissue Engineering. Nanomaterials 2017, 7, 436.

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