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Open AccessArticle

Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability

1
School of Chemical Engineering & Pharmaceutics, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China
2
School of Medicine, Henan University of Science & Technology, 263# Kaiyuan Road, Luoyang 471023, China
*
Author to whom correspondence should be addressed.
Nanomaterials 2017, 7(11), 387; https://doi.org/10.3390/nano7110387
Received: 23 September 2017 / Revised: 27 October 2017 / Accepted: 8 November 2017 / Published: 13 November 2017
(This article belongs to the Special Issue Nanoporous Gold and Other Related Materials)
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Abstract

A strategy for constructing polyion complex vesicles (PICsomes) with asymmetric structure is described. Poly(methylacrylic acid)-block-poly(N-isopropylacrylamide) modified gold nanoparticles (PMAA-b[email protected] NPs) were prepared and then assembled with poly(ethylene glycol)-block-poly[1-methyl-3-(2-methacryloyloxy propylimidazolium bromine)] (PEG-b-PMMPImB) via polyion complex of PMMA and PMMPImB. After removing the Au NPs template, asymmetric PICsomes composed of a PNIPAm inner-shell, PIC wall, and PEG outer-corona were obtained. These PICsomes have low protein absorption and thermally tunable permeability, provided by the PEG outer-corona and the PNIPAm inner-shell, respectively. Moreover, PICsome size can be tailored by using templates of predetermined sizes. This novel strategy for constructing asymmetric PICsomes with well-defined properties and controllable size is valuable for applications such as drug delivery, catalysis and monitoring of chemical reactions, and biomimetics. View Full-Text
Keywords: asymmetric polymersome; polyion complex; block copolymer; gold template; permeability asymmetric polymersome; polyion complex; block copolymer; gold template; permeability
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Li, J.; Liang, L.; Liang, J.; Wu, W.; Zhou, H.; Guo, J. Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability. Nanomaterials 2017, 7, 387.

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