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Open AccessArticle

Ex-Vivo Tissues Engineering Modeling for Reconstructive Surgery Using Human Adult Adipose Stem Cells and Polymeric Nanostructured Matrix

1
Department of Chemistry, Biology and Biotechnologies, Biochemistry and Molecular Biology Unit, University of Perugia, Via del Giochetto, Perugia 06122, Italy
2
Unità Operativa Chirurgia Plastica e Ricostruttiva, ASL 1 Umbria, Città di Castello 06012, Italy
*
Author to whom correspondence should be addressed.
Current address: Angelantoni Life Science, Località Cimacolle, 464 06056 Massa Martana (Perugia), Italy
Academic Editor: Subramanian Tamil Selvan
Nanomaterials 2016, 6(4), 57; https://doi.org/10.3390/nano6040057
Received: 29 January 2016 / Revised: 9 March 2016 / Accepted: 14 March 2016 / Published: 31 March 2016
(This article belongs to the Special Issue Nanomaterials for Tissue Engineering)
The major challenge for stem cell translation regenerative medicine is the regeneration of damaged tissues by creating biological substitutes capable of recapitulating the missing function in the recipient host. Therefore, the current paradigm of tissue engineering strategies is the combination of a selected stem cell type, based on their capability to differentiate toward committed cell lineages, and a biomaterial, that, due to own characteristics (e.g., chemical, electric, mechanical property, nano-topography, and nanostructured molecular components), could serve as active scaffold to generate a bio-hybrid tissue/organ. Thus, effort has been made on the generation of in vitro tissue engineering modeling. Here, we present an in vitro model where human adipose stem cells isolated from lipoaspirate adipose tissue and breast adipose tissue, cultured on polymeric INTEGRA® Meshed Bilayer Wound Matrix (selected based on conventional clinical applications) are evaluated for their potential application for reconstructive surgery toward bone and adipose tissue. We demonstrated that human adipose stem cells isolated from lipoaspirate and breast tissue have similar stemness properties and are suitable for tissue engineering applications. Finally, the overall results highlighted lipoaspirate adipose tissue as a good source for the generation of adult adipose stem cells. View Full-Text
Keywords: adult mesenchymal stem cells isolation and culture; stem cells and biomaterial interaction; INTEGRA®; regenerative medicine adult mesenchymal stem cells isolation and culture; stem cells and biomaterial interaction; INTEGRA®; regenerative medicine
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MDPI and ACS Style

Morena, F.; Argentati, C.; Calzoni, E.; Cordellini, M.; Emiliani, C.; D’Angelo, F.; Martino, S. Ex-Vivo Tissues Engineering Modeling for Reconstructive Surgery Using Human Adult Adipose Stem Cells and Polymeric Nanostructured Matrix. Nanomaterials 2016, 6, 57.

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