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Open AccessCommunication

The Assembly of DNA Amphiphiles at Liquid Crystal-Aqueous Interface

Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China
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Academic Editors: Leonid Gurevich and John H. T. Luong
Nanomaterials 2016, 6(12), 229; https://doi.org/10.3390/nano6120229
Received: 30 June 2016 / Revised: 19 October 2016 / Accepted: 17 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue DNA-Based Nanotechnology)
In this article, we synthesized a type of DNA amphiphiles (called DNA-lipids) and systematically studied its assembly behavior at the liquid crystal (LC)—aqueous interface. It turned out that the pure DNA-lipids at various concentrations cannot trigger the optical transition of liquid crystals from planar anchoring to homeotropic anchoring at the liquid crystal—aqueous interface. The co-assembly of DNA-lipid and l-dilauroyl phosphatidylcholine (l-DLPC) indicated that the DLPC assembled all over the LC-aqueous interface, and DNA-lipids prefer to couple with LC in certain areas, particularly in polarized and fluorescent image, forming micron sized net-like structures. The addition of DNA complementary to DNA-lipids forming double stranded DNA-lipids caused de-assembly of DNA-lipids from LC-aqueous interface, resulting in the disappearance of net-like structures, which can be visualized through polarized microscope. The optical changes combined with DNA unique designable property and specific interaction with wide range of target molecules, the DNA-lipids decorated LC-aqueous interface would provide a new platform for biological sensing and diagnosis. View Full-Text
Keywords: liquid crystal; interface; self-assembly; DNA amphiphiles; detection liquid crystal; interface; self-assembly; DNA amphiphiles; detection
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MDPI and ACS Style

Zhou, J.; Dong, Y.; Zhang, Y.; Liu, D.; Yang, Z. The Assembly of DNA Amphiphiles at Liquid Crystal-Aqueous Interface. Nanomaterials 2016, 6, 229.

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