Next Article in Journal
Influence of External Gaseous Environments on the Electrical Properties of ZnO Nanostructures Obtained by a Hydrothermal Method
Next Article in Special Issue
Amorphous Silica Particles Relevant in Food Industry Influence Cellular Growth and Associated Signaling Pathways in Human Gastric Carcinoma Cells
Previous Article in Journal
The Chemical Deposition Method for the Decoration of Palladium Particles on Carbon Nanofibers with Rapid Conductivity Changes
Previous Article in Special Issue
The Dispersion State of Tangled Multi-Walled Carbon Nanotubes Affects Their Cytotoxicity
Open AccessArticle

Titanium Dioxide Nanoparticle-Biomolecule Interactions Influence Oral Absorption

1
Division of Applied Food System, Major of Food Science and Technology, Seoul Women’s University, Seoul 01797, Korea
2
Department of Chemistry and Medical Chemistry, Yonsei University, Wonju, Gangwondo 26493, Korea
3
Seoul Institute, National Forensic Service, 139, Jiyang-ro, Yangcheon-gu, Seoul 08036, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Eleonore Fröhlich
Nanomaterials 2016, 6(12), 225; https://doi.org/10.3390/nano6120225
Received: 19 October 2016 / Revised: 14 November 2016 / Accepted: 21 November 2016 / Published: 29 November 2016
(This article belongs to the Special Issue Cytotoxicity of Nanoparticles)
Titanium dioxide (TiO2) nanoparticles (NPs) have been widely applied in various industrial fields, such as electronics, packaging, food, and cosmetics. Accordingly, concerns about the potential toxicity of TiO2 NPs have increased. In order to comprehend their in vivo behavior and potential toxicity, we must evaluate the interactions between TiO2 NPs and biomolecules, which can alter the physicochemical properties and the fate of NPs under physiological conditions. In the present study, in vivo solubility, oral absorption, tissue distribution, and excretion kinetics of food grade TiO2 (f-TiO2) NPs were evaluated following a single-dose oral administration to rats and were compared to those of general grade TiO2 (g-TiO2) NPs. The effect of the interactions between the TiO2 NPs and biomolecules, such as glucose and albumin, on oral absorption was also investigated, with the aim of determining the surface interactions between them. The intestinal transport pathway was also assessed using 3-dimensional culture systems. The results demonstrate that slightly higher oral absorption of f-TiO2 NPs compared to g-TiO2 NPs could be related to their intestinal transport mechanism by microfold (M) cells, however, most of the NPs were eliminated through the feces. Moreover, the biokinetics of f-TiO2 NPs was highly dependent on their interaction with biomolecules, and the dispersibility was affected by modified surface chemistry. View Full-Text
Keywords: titanium dioxide; interaction; biomolecule; oral absorption; intestinal transport titanium dioxide; interaction; biomolecule; oral absorption; intestinal transport
Show Figures

Figure 1

MDPI and ACS Style

Jo, M.-R.; Yu, J.; Kim, H.-J.; Song, J.H.; Kim, K.-M.; Oh, J.-M.; Choi, S.-J. Titanium Dioxide Nanoparticle-Biomolecule Interactions Influence Oral Absorption. Nanomaterials 2016, 6, 225.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop