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DNA under Force: Mechanics, Electrostatics, and Hydration

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Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA
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Department of Physics, George Washington University, Washington, DC 20052, USA
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Department of Bioengineering, Rice University, Houston, TX 77005, USA
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Authors to whom correspondence should be addressed.
Academic Editor: Stephen Ralph
Nanomaterials 2015, 5(1), 246-267; https://doi.org/10.3390/nano5010246
Received: 9 December 2014 / Revised: 16 January 2015 / Accepted: 12 February 2015 / Published: 25 February 2015
(This article belongs to the Special Issue Frontiers in Nucleic Acid Nanotechnology)
Quantifying the basic intra- and inter-molecular forces of DNA has helped us to better understand and further predict the behavior of DNA. Single molecule technique elucidates the mechanics of DNA under applied external forces, sometimes under extreme forces. On the other hand, ensemble studies of DNA molecular force allow us to extend our understanding of DNA molecules under other forces such as electrostatic and hydration forces. Using a variety of techniques, we can have a comprehensive understanding of DNA molecular forces, which is crucial in unraveling the complex DNA functions in living cells as well as in designing a system that utilizes the unique properties of DNA in nanotechnology. View Full-Text
Keywords: DNA; mechanics; electrostatics; hydration DNA; mechanics; electrostatics; hydration
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Li, J.; Wijeratne, S.S.; Qiu, X.; Kiang, C.-H. DNA under Force: Mechanics, Electrostatics, and Hydration. Nanomaterials 2015, 5, 246-267.

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