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Article

A Curcumin-Decorated Nanozyme with ROS Scavenging and Anti-Inflammatory Properties for Neuroprotection

by
Feng Gao
1,2,3,
Wenyu Liang
2,3,
Qixin Chen
2,3,
Bairu Chen
1,2,
Yuchen Liu
1,2,
Zhibo Liu
1,2,
Xu Xu
1,2,3,*,
Rongrong Zhu
1,2,3 and
Liming Cheng
1,2,3,*
1
Department of Orthopedics, Tongji Hospital Affiliated to Tongji University, School of Medicine, Tongji University, Shanghai 200331, China
2
Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, School of Life Science and Technology, Tongji University, Shanghai 200065, China
3
Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200065, China
*
Authors to whom correspondence should be addressed.
Nanomaterials 2024, 14(5), 389; https://doi.org/10.3390/nano14050389
Submission received: 31 January 2024 / Revised: 16 February 2024 / Accepted: 18 February 2024 / Published: 20 February 2024
(This article belongs to the Special Issue Advanced Studies in Bionanomaterials)
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Abstract

Disordered reactive oxygen/nitrogen species are a common occurrence in various diseases, which usually cause cellular oxidative damage and inflammation. Despite the wide range of applications for biomimetic nanoparticles with antioxidant or anti-inflammatory properties, designs that seamlessly integrate these two abilities with a synergistic effect in a simple manner are seldom reported. In this study, we developed a novel PEI-Mn composite nanoparticle (PM NP) using a chelation method, and the curcumin was loaded onto PM NPs via metal–phenol coordination to form PEI-Mn@curcumin nanoparticles (PMC NPs). PMC NPs possessed excellent dispersibility and cytocompatibility, was engineered to serve as an effective nanozyme, and exhibited specific SOD-like and CAT-like activities. In addition, the incorporation of curcumin granted PMC NPs the ability to effectively suppress the expression of inflammatory cytokines in microglia induced by LPS. As curcumin also has antioxidant properties, it further amplified the synergistic efficiency of ROS scavenging. Significantly, PMC NPs effectively scavenged ROS triggered by H2O2 in SIM-A9 microglia cells and Neuro-2a cells. PMC NPs also considerably mitigated DNA and lipid oxidation in Neuro-2a cells and demonstrated an increase in cell viability under various H2O2 concentrations. These properties suggest that PMC NPs have significant potential in addressing excessive ROS and inflammation related to neural diseases.
Keywords: nanozyme; ROS scavenging; anti-inflammatory; neuroprotective nanozyme; ROS scavenging; anti-inflammatory; neuroprotective

Share and Cite

MDPI and ACS Style

Gao, F.; Liang, W.; Chen, Q.; Chen, B.; Liu, Y.; Liu, Z.; Xu, X.; Zhu, R.; Cheng, L. A Curcumin-Decorated Nanozyme with ROS Scavenging and Anti-Inflammatory Properties for Neuroprotection. Nanomaterials 2024, 14, 389. https://doi.org/10.3390/nano14050389

AMA Style

Gao F, Liang W, Chen Q, Chen B, Liu Y, Liu Z, Xu X, Zhu R, Cheng L. A Curcumin-Decorated Nanozyme with ROS Scavenging and Anti-Inflammatory Properties for Neuroprotection. Nanomaterials. 2024; 14(5):389. https://doi.org/10.3390/nano14050389

Chicago/Turabian Style

Gao, Feng, Wenyu Liang, Qixin Chen, Bairu Chen, Yuchen Liu, Zhibo Liu, Xu Xu, Rongrong Zhu, and Liming Cheng. 2024. "A Curcumin-Decorated Nanozyme with ROS Scavenging and Anti-Inflammatory Properties for Neuroprotection" Nanomaterials 14, no. 5: 389. https://doi.org/10.3390/nano14050389

APA Style

Gao, F., Liang, W., Chen, Q., Chen, B., Liu, Y., Liu, Z., Xu, X., Zhu, R., & Cheng, L. (2024). A Curcumin-Decorated Nanozyme with ROS Scavenging and Anti-Inflammatory Properties for Neuroprotection. Nanomaterials, 14(5), 389. https://doi.org/10.3390/nano14050389

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