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Article

Could Iron-Nitrogen Doping Modulate the Cytotoxicity of TiO2 Nanoparticles?

1
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania
2
Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania
3
National Institute of Materials Physics (NIMP), Atomistilor 405A, Magurele, 077125 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Wenyan Yin
Nanomaterials 2022, 12(5), 770; https://doi.org/10.3390/nano12050770
Received: 23 January 2022 / Revised: 22 February 2022 / Accepted: 23 February 2022 / Published: 25 February 2022
Titanium dioxide nanoparticles (TiO2 NPs) are found in several products on the market that include paints, smart textiles, cosmetics and food products. Besides these, TiO2 NPs are intensively researched for their use in biomedicine, agriculture or installations to produce energy. Taking into account that several risks have been associated with the use of TiO2 NPs, our aim was to provide TiO2 NPs with improved qualities and lower toxicity to humans and the environment. Pure TiO2 P25 NPs and the same NPs co-doped with iron (1%) and nitrogen atoms (P25-Fe(1%)-N NPs) by hydrothermal treatment to increase the photocatalytic activity in the visible light spectrum were in vitro evaluated in the presence of human lung cells. After 24 and 72 h of incubation, the oxidative stress was initiated in a time- and dose-dependent manner with major differences between pure P25 and P25-Fe(1%)-N NPs as revealed by malondialdehyde and reactive oxygen species levels. Additionally, a lower dynamic of autophagic vacuoles formation was observed in cells exposed to Fe-N-doped P25 NPs compared to the pure ones. Therefore, our results suggest that Fe-N doping of TiO2 NPs can represent a valuable alternative to the conventional P25 Degussa particles in industrial and medical applications. View Full-Text
Keywords: titanium dioxide; P25 Degussa nanoparticles; iron doping; photocatalysts; human cytotoxicity titanium dioxide; P25 Degussa nanoparticles; iron doping; photocatalysts; human cytotoxicity
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MDPI and ACS Style

Nica, I.C.; Miu, B.A.; Stan, M.S.; Diamandescu, L.; Dinischiotu, A. Could Iron-Nitrogen Doping Modulate the Cytotoxicity of TiO2 Nanoparticles? Nanomaterials 2022, 12, 770. https://doi.org/10.3390/nano12050770

AMA Style

Nica IC, Miu BA, Stan MS, Diamandescu L, Dinischiotu A. Could Iron-Nitrogen Doping Modulate the Cytotoxicity of TiO2 Nanoparticles? Nanomaterials. 2022; 12(5):770. https://doi.org/10.3390/nano12050770

Chicago/Turabian Style

Nica, Ionela Cristina, Bogdan Andrei Miu, Miruna S. Stan, Lucian Diamandescu, and Anca Dinischiotu. 2022. "Could Iron-Nitrogen Doping Modulate the Cytotoxicity of TiO2 Nanoparticles?" Nanomaterials 12, no. 5: 770. https://doi.org/10.3390/nano12050770

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