Next Article in Journal
Nanoparticle-Induced m6A RNA Modification: Detection Methods, Mechanisms and Applications
Previous Article in Journal
Advancement of Fluorescent and Structural Properties of Bovine Serum Albumin-Gold Bioconjugates in Normal and Heavy Water with pH Conditioning and Ageing
Article

Micro/Nanoarchitectonics of 3D Printed Scaffolds with Excellent Biocompatibility Prepared Using Femtosecond Laser Two-Photon Polymerization for Tissue Engineering Applications

by 1,2,3,*, 1,2,3, 1,2,3 and 1,2,3
1
Faculty of Materials and Manufacturing, Institute of Laser Engineering, Beijing University of Technology, Beijing 100124, China
2
Key Laboratory of Trans-Scale Laser Manufacturing Technology, Beijing University of Technology, Ministry of Education, Beijing 100124, China
3
Beijing Engineering Research Center of 3D Printing for Digital Medical Health, Beijing University of Technology, Beijing 100124, China
*
Author to whom correspondence should be addressed.
Academic Editors: Katsuhiko Ariga, Fabien Grasset and Yann Molard
Nanomaterials 2022, 12(3), 391; https://doi.org/10.3390/nano12030391
Received: 29 December 2021 / Revised: 18 January 2022 / Accepted: 20 January 2022 / Published: 25 January 2022
The fabrication of high-precision scaffolds with excellent biocompatibility for tissue engineering has become a research hotspot. Two-photon polymerization (TPP) can break the optical diffraction limit and is used to fabricate high-resolution three-dimensional (3D) microstructures. In this study, the biological properties, and machinability of photosensitive gelatin methacrylate (GelMA) hydrogel solutions are investigated, and the biocompatibility of 3D scaffolds using a photosensitive GelMA hydrogel solution fabricated by TPP is also evaluated. The biological properties of photosensitive GelMA hydrogel solutions are evaluated by analyzing their cytotoxicity, swelling ratio, and degradation ratio. The experimental results indicate that: (1) photosensitive GelMA hydrogel solutions with remarkable biological properties and processability are suitable for cell attachment. (2) a micro/nano 3D printed scaffold with good biocompatibility is fabricated using a laser scanning speed of 150 μm/s, laser power of 7.8 mW, layer distance of 150 nm and a photosensitive GelMA hydrogel solution with a concentration of 12% (w/v). Micro/nano additive manufacturing will have broad application prospects in the tissue engineering field. View Full-Text
Keywords: micro/nano 3D printed scaffold; femtosecond laser; two-photon polymerization micro/nano 3D printed scaffold; femtosecond laser; two-photon polymerization
Show Figures

Figure 1

MDPI and ACS Style

Yuan, Y.; Chen, L.; Shi, Z.; Chen, J. Micro/Nanoarchitectonics of 3D Printed Scaffolds with Excellent Biocompatibility Prepared Using Femtosecond Laser Two-Photon Polymerization for Tissue Engineering Applications. Nanomaterials 2022, 12, 391. https://doi.org/10.3390/nano12030391

AMA Style

Yuan Y, Chen L, Shi Z, Chen J. Micro/Nanoarchitectonics of 3D Printed Scaffolds with Excellent Biocompatibility Prepared Using Femtosecond Laser Two-Photon Polymerization for Tissue Engineering Applications. Nanomaterials. 2022; 12(3):391. https://doi.org/10.3390/nano12030391

Chicago/Turabian Style

Yuan, Yanping, Lei Chen, Ziyuan Shi, and Jimin Chen. 2022. "Micro/Nanoarchitectonics of 3D Printed Scaffolds with Excellent Biocompatibility Prepared Using Femtosecond Laser Two-Photon Polymerization for Tissue Engineering Applications" Nanomaterials 12, no. 3: 391. https://doi.org/10.3390/nano12030391

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop