Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

Ramírez-Morales, Maria Antonieta; Goldt, Anastasia E.; Kalachikova, Polina M.; Ramirez B., Javier A.; Suzuki, Masashi; Zhigach, Alexey N.; Ben Salah, Asma; Shurygina, Liliya I.; Shandakov, Sergey D.; Zatsepin, Timofei; Krasnikov, Dmitry V.; Maekawa, Toru; Nikolaev, Evgeny N.; Nasibulin, Albert G.

doi:10.3390/nano12162869

Open AccessArticle

Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

by

Maria Antonieta Ramírez-Morales

^1,2,3

,

Anastasia E. Goldt

^1,*

,

Polina M. Kalachikova

^1,4,

Javier A. Ramirez B.

¹,

Masashi Suzuki

^5,6,

Alexey N. Zhigach

⁷,

Asma Ben Salah

^5,6,

Liliya I. Shurygina

⁸,

Sergey D. Shandakov

⁸,

Timofei Zatsepin

¹

,

Dmitry V. Krasnikov

¹

,

Toru Maekawa

^5,6,

Evgeny N. Nikolaev

¹ and

Albert G. Nasibulin

^1,4,*

¹

Skolkovo Institute of Science and Technology, 3 Nobel Street, 121205 Moscow, Russia

²

Hi-QNano s.r.l., Via Barsanti No. 1, 73010 Arnesano, Italy

³

Department of Engineering of Innovation, University of Salento, Via per Arnesano km 1, 73100 Lecce, Italy

⁴

School of Chemical Engineering, Aalto University, Kemistintie 1, 02015 Espoo, Finland

⁵

Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe 350-8585, Saitama, Japan

⁶

Bio-Nano Electronics Research Center, Toyo University, Kawagoe 350-8585, Saitama, Japan

⁷

V.L. Talrose Institute for Energy Problems of Chemical Physics at Federal Research Center of Chemical Physics, Russian Academy of Sciences, Leninsky Prospect 38 Building 2, 119334 Moscow, Russia

⁸

Kemerovo State University, Krasnaya 6, 650043 Kemerovo, Russia

^*

Authors to whom correspondence should be addressed.

Nanomaterials 2022, 12(16), 2869; https://doi.org/10.3390/nano12162869

Submission received: 20 June 2022 / Revised: 28 July 2022 / Accepted: 18 August 2022 / Published: 20 August 2022

(This article belongs to the Section Synthesis, Interfaces and Nanostructures)

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Abstract

Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.

Keywords: ferromagnetic particles; core–shell nanoparticles; magnetic hyperthermia; iron nanoparticles; flow-levitation method

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MDPI and ACS Style

Ramírez-Morales, M.A.; Goldt, A.E.; Kalachikova, P.M.; Ramirez B., J.A.; Suzuki, M.; Zhigach, A.N.; Ben Salah, A.; Shurygina, L.I.; Shandakov, S.D.; Zatsepin, T.; et al. Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy. Nanomaterials 2022, 12, 2869. https://doi.org/10.3390/nano12162869

AMA Style

Ramírez-Morales MA, Goldt AE, Kalachikova PM, Ramirez B. JA, Suzuki M, Zhigach AN, Ben Salah A, Shurygina LI, Shandakov SD, Zatsepin T, et al. Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy. Nanomaterials. 2022; 12(16):2869. https://doi.org/10.3390/nano12162869

Chicago/Turabian Style

Ramírez-Morales, Maria Antonieta, Anastasia E. Goldt, Polina M. Kalachikova, Javier A. Ramirez B., Masashi Suzuki, Alexey N. Zhigach, Asma Ben Salah, Liliya I. Shurygina, Sergey D. Shandakov, Timofei Zatsepin, and et al. 2022. "Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy" Nanomaterials 12, no. 16: 2869. https://doi.org/10.3390/nano12162869

APA Style

Ramírez-Morales, M. A., Goldt, A. E., Kalachikova, P. M., Ramirez B., J. A., Suzuki, M., Zhigach, A. N., Ben Salah, A., Shurygina, L. I., Shandakov, S. D., Zatsepin, T., Krasnikov, D. V., Maekawa, T., Nikolaev, E. N., & Nasibulin, A. G. (2022). Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy. Nanomaterials, 12(16), 2869. https://doi.org/10.3390/nano12162869

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Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

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