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Article

Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles

1
Faculty of Physics, Lomonosov Moscow State University, 119991 Moscow, Russia
2
Faculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia
3
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia
4
Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden
5
Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Russia
*
Authors to whom correspondence should be addressed.
Academic Editors: Ehrenfried Zschech, Rodrigo Martins, Eva Olsson, Sabrina Sartori and Robert Sinclair
Nanomaterials 2021, 11(9), 2167; https://doi.org/10.3390/nano11092167
Received: 30 July 2021 / Revised: 21 August 2021 / Accepted: 22 August 2021 / Published: 25 August 2021
Silicon nanoparticles (SiNP) are currently of great interest, especially in biomedicine, because of their unique physicochemical properties combined with biodegradability. SiNPs can be obtained in various ways and can have either a non-porous solid (sol-) or porous (por-) structure. In this work, we carry out detailed optical monitoring of sol- and por-SiNP biodegradation using Raman and photoluminescence (PL) micro-spectroscopy. SiNPs were obtained by ultrasound grinding of sol- or por-silicon nanowires, created by silver-assisted chemical etching of crystalline Si with different doping levels. In this case, sol-SiNPs consist of nanocrystals 30 nm in size, while por-SiNPs consist of small 3 nm nanocrystals and 16 nm pores. Both SiNPs show low in vitro cytotoxicity towards MCF-7 and HEK293T cells up to 800 μg/mL. The appearance of the F-band (blue–yellow) PL, as well as a decrease in the intensity of the Raman signal, indicate the gradual dissolution of the sol-SiNPs during 20 days of incubation. At the same time, the rapid dissolution of por-SiNP within 24 h is identified by the quenching of their S-band (red) PL and the disappearance of the Raman signal. The obtained results are important for development of intelligent biodegradable drug delivery systems based on SiNPs. View Full-Text
Keywords: silicon nanoparticles; porous nanoparticles; solid nanoparticles; biodegradation; Raman; photoluminescence; cytotoxicity; biophotonics silicon nanoparticles; porous nanoparticles; solid nanoparticles; biodegradation; Raman; photoluminescence; cytotoxicity; biophotonics
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MDPI and ACS Style

Gongalsky, M.B.; Pervushin, N.V.; Maksutova, D.E.; Tsurikova, U.A.; Putintsev, P.P.; Gyuppenen, O.D.; Evstratova, Y.V.; Shalygina, O.A.; Kopeina, G.S.; Kudryavtsev, A.A.; Zhivotovsky, B.; Osminkina, L.A. Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles. Nanomaterials 2021, 11, 2167. https://doi.org/10.3390/nano11092167

AMA Style

Gongalsky MB, Pervushin NV, Maksutova DE, Tsurikova UA, Putintsev PP, Gyuppenen OD, Evstratova YV, Shalygina OA, Kopeina GS, Kudryavtsev AA, Zhivotovsky B, Osminkina LA. Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles. Nanomaterials. 2021; 11(9):2167. https://doi.org/10.3390/nano11092167

Chicago/Turabian Style

Gongalsky, Maxim B., Nikolay V. Pervushin, Daria E. Maksutova, Uliana A. Tsurikova, Pavel P. Putintsev, Oleg D. Gyuppenen, Yana V. Evstratova, Olga A. Shalygina, Gelina S. Kopeina, Andrey A. Kudryavtsev, Boris Zhivotovsky, and Liubov A. Osminkina. 2021. "Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles" Nanomaterials 11, no. 9: 2167. https://doi.org/10.3390/nano11092167

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