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Article

Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations

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Laboratory of Nano-Bioengineering, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Highway, 115409 Moscow, Russia
2
Laboratoire de Recherche en Nanosciences, LRN-EA4682, Université de Reims Champagne-Ardenne, 51 Rue Cognacq Jay, 51100 Reims, France
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Laboratory of Experimental Diagnostics and Biotherapy of Cancer, N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoe Highway, 115478 Moscow, Russia
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Institut de Chimie Moléculaire de Reims, Université de Reims Champagne-Ardenne, 51 Rue Cognacq Jay, 51100 Reims, France
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Laboratory of Immunopathology, Department of Clinical Immunology and Allergology Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskaya Str., 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Zili Sideratou
Nanomaterials 2021, 11(9), 2160; https://doi.org/10.3390/nano11092160
Received: 10 July 2021 / Revised: 5 August 2021 / Accepted: 20 August 2021 / Published: 24 August 2021
Designing nanoprobes in which quantum dots (QDs) are used as photoluminescent labels is an especially promising line of research due to their possible medical applications ranging from disease diagnosis to drug delivery. In spite of the significant progress made in designing such nanoprobes, the properties of their individual components, i.e., photoluminescent QDs, vectorization moieties, and pharmacological agents, still require further optimization to enhance the efficiency of diagnostic or therapeutic procedures. Here, we have developed a method of engineering compact multifunctional nanoprobes based on functional components with optimized properties: bright photoluminescence of CdSe/ZnS (core/shell) QDs, a compact and effective antitumor agent (an acridine derivative), and direct conjugation of the components via electrostatic interaction, which provides a final hydrodynamic diameter of nanoprobes smaller than 15 nm. Due to the possibility of conjugating various biomolecules with hydroxyl and carboxyl moieties to QDs, the method represents a versatile approach to the biomarker-recognizing molecule imaging of the delivery of the active substance as part of compact nanoprobes. View Full-Text
Keywords: quantum dots; multifunctional nanoprobes; acridine derivatives; G-quadruplex quantum dots; multifunctional nanoprobes; acridine derivatives; G-quadruplex
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MDPI and ACS Style

Linkov, P.; Samokhvalov, P.; Baryshnikova, M.; Laronze-Cochard, M.; Sapi, J.; Karaulov, A.; Nabiev, I. Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations. Nanomaterials 2021, 11, 2160. https://doi.org/10.3390/nano11092160

AMA Style

Linkov P, Samokhvalov P, Baryshnikova M, Laronze-Cochard M, Sapi J, Karaulov A, Nabiev I. Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations. Nanomaterials. 2021; 11(9):2160. https://doi.org/10.3390/nano11092160

Chicago/Turabian Style

Linkov, Pavel, Pavel Samokhvalov, Maria Baryshnikova, Marie Laronze-Cochard, Janos Sapi, Alexander Karaulov, and Igor Nabiev. 2021. "Conjugates of Ultrasmall Quantum Dots and Acridine Derivatives as Prospective Nanoprobes for Intracellular Investigations" Nanomaterials 11, no. 9: 2160. https://doi.org/10.3390/nano11092160

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