Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes

Moratin, Helena; Ickrath, Pascal; Scherzad, Agmal; Meyer, Till Jasper; Naczenski, Sebastian; Hagen, Rudolf; Hackenberg, Stephan

doi:10.3390/nano11030629

Open AccessArticle

Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes

by

Helena Moratin

^*,†,

Pascal Ickrath

^*,†

,

Agmal Scherzad

,

Till Jasper Meyer

,

Sebastian Naczenski

,

Rudolf Hagen

and

Stephan Hackenberg

Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg, 97080 Wuerzburg, Germany

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Nanomaterials 2021, 11(3), 629; https://doi.org/10.3390/nano11030629

Submission received: 7 February 2021 / Revised: 21 February 2021 / Accepted: 26 February 2021 / Published: 3 March 2021

(This article belongs to the Special Issue Cytotoxicity and Genotoxicity of Nanomaterials)

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Abstract

Zinc oxide nanoparticles (ZnO-NP) are commonly used for a variety of applications in everyday life. In addition, due to its versatility, nanotechnology supports promising approaches in the medical sector. NP can act as drug-carriers in the context of targeted chemo- or immunotherapy, and might also exhibit autonomous immune-modulatory characteristics. Knowledge of potential immunosuppressive or stimulating effects of NP is indispensable for the safety of consumers as well as patients. In this study, primary human peripheral blood lymphocytes of 9 donors were treated with different sub-cytotoxic concentrations of ZnO-NP for the duration of 1, 2, or 3 days. Flow cytometry was performed to investigate changes in the activation profile and the proportion of T cell subpopulations. ZnO-NP applied in this study did not induce any significant alterations in the examined markers, indicating their lack of impairment in terms of immune modulation. However, physicochemical characteristics exert a major influence on NP-associated bioactivity. To allow a precise simulation of the complex molecular processes of immune modulation, a physiological model including the different components of an immune response is needed.

Keywords: zinc oxide nanoparticles; immunomodulation; T cell subpopulations

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MDPI and ACS Style

Moratin, H.; Ickrath, P.; Scherzad, A.; Meyer, T.J.; Naczenski, S.; Hagen, R.; Hackenberg, S. Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes. Nanomaterials 2021, 11, 629. https://doi.org/10.3390/nano11030629

AMA Style

Moratin H, Ickrath P, Scherzad A, Meyer TJ, Naczenski S, Hagen R, Hackenberg S. Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes. Nanomaterials. 2021; 11(3):629. https://doi.org/10.3390/nano11030629

Chicago/Turabian Style

Moratin, Helena, Pascal Ickrath, Agmal Scherzad, Till Jasper Meyer, Sebastian Naczenski, Rudolf Hagen, and Stephan Hackenberg. 2021. "Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes" Nanomaterials 11, no. 3: 629. https://doi.org/10.3390/nano11030629

APA Style

Moratin, H., Ickrath, P., Scherzad, A., Meyer, T. J., Naczenski, S., Hagen, R., & Hackenberg, S. (2021). Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes. Nanomaterials, 11(3), 629. https://doi.org/10.3390/nano11030629

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Investigation of the Immune Modulatory Potential of Zinc Oxide Nanoparticles in Human Lymphocytes

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