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Article

A Chemosensor Based on Gold Nanoparticles and Dithiothreitol (DTT) for Acrylamide Electroanalysis

1
Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India
2
Nanobioelectronic Laboratory, Department of Biotechnology, Delhi Technological University, Shahbad Daulatpur, Bawana, New Delhi 110042, India
3
School of Chemistry, University College Cork, T12 YN60 Cork, Ireland
*
Author to whom correspondence should be addressed.
Academic Editor: Dong-Joo Kim
Nanomaterials 2021, 11(10), 2610; https://doi.org/10.3390/nano11102610
Received: 21 August 2021 / Revised: 22 September 2021 / Accepted: 1 October 2021 / Published: 4 October 2021
Rapid and simple electroanalysis of acrylamide (ACR) was feasible by a gold electrode modified with gold nanoparticles (AuNPs) and dithiothreitol (DTT) with enhanced detection sensitivity and selectivity. The roughness of bare gold (Au) increased from 0.03 μm to 0.04 μm when it was decorated with AuNPs. The self-assembly between DTT and AuNPs resulted in a surface roughness of 0.09 μm. The DTT oxidation occurred at +0.92 V. The Au/AuNPs/DTT surface exhibited a surface roughness of 0.24 μm after its exposure to ACR with repeated analysis. SEM imaging illustrated the formation of a polymer layer on the Au/AuNPs/DTT surface. Surface plasmon resonance analysis confirmed the presence of AuNPs and DTT on the gold electrode and the binding of ACR to the electrode’s active surface area. The peak area obtained by differential pulse voltammetry was inversely proportional to the ACR concentrations. The limit of detection (LOD) and the limit of quantitation (LOQ) were estimated to be 3.11 × 10−9 M and 1 × 10−8 M, respectively, with wide linearity ranging from 1 × 10−8 M to 1 × 10−3 M. The estimated levels of ACR in potato chips and coffee samples by the sensor were in agreement with those of high-performance liquid chromatography. View Full-Text
Keywords: acrylamide; dithiothreitol; differential pulse voltammetry; impedance spectroscopy; surface plasmon resonance acrylamide; dithiothreitol; differential pulse voltammetry; impedance spectroscopy; surface plasmon resonance
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MDPI and ACS Style

Alam, S.; Augustine, S.; Narayan, T.; Luong, J.H.T.; Malhotra, B.D.; Khare, S.K. A Chemosensor Based on Gold Nanoparticles and Dithiothreitol (DTT) for Acrylamide Electroanalysis. Nanomaterials 2021, 11, 2610. https://doi.org/10.3390/nano11102610

AMA Style

Alam S, Augustine S, Narayan T, Luong JHT, Malhotra BD, Khare SK. A Chemosensor Based on Gold Nanoparticles and Dithiothreitol (DTT) for Acrylamide Electroanalysis. Nanomaterials. 2021; 11(10):2610. https://doi.org/10.3390/nano11102610

Chicago/Turabian Style

Alam, Shahenvaz, Shine Augustine, Tarun Narayan, John H.T. Luong, Bansi D. Malhotra, and Sunil K. Khare. 2021. "A Chemosensor Based on Gold Nanoparticles and Dithiothreitol (DTT) for Acrylamide Electroanalysis" Nanomaterials 11, no. 10: 2610. https://doi.org/10.3390/nano11102610

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