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Article

One-Pot Synthesis of Thiol-Modified Liquid Crystals Conjugated Fluorescent Gold Nanoclusters

1
School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan
2
International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan
3
Institut de Recherche en Sciences de la Santé (IRSS-DRCO), 03 B.P 7192, Ouagadougou 03, Nanoro, Burkina Faso
4
Dharma Husada Nursing Academy, Kediri, East Java 64114, Indonesia
5
Department of Electrical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia
6
Nahdlatul Ulama Surabaya University, Surabaya 60111, Indonesia
7
Department of Biomedical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia
8
Graduate Institute of Biomedical Optomechatronics, Taipei Medical University, Taipei 11031, Taiwan
9
Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(9), 1755; https://doi.org/10.3390/nano10091755
Received: 2 August 2020 / Revised: 2 September 2020 / Accepted: 4 September 2020 / Published: 6 September 2020
(This article belongs to the Special Issue Nanobiophotonics, Photomedicine, and Imaging)
Gold nanoclusters (AuNCs) and liquid crystals (LCs) have shown great potential in nanobiotechnology applications due to their unique optical and structural properties. Herein, the hardcore of the 4-cyano biphenyl group for commonly used LCs of 4-cyano-4′-pentylbiphenyl (5CB) was utilized to synthesize 4′-(2-mercaptoethyl)-(1,1′-biphenyl)-4-carbonitrile (TAT-12) based on Suzuki coupling and Appel reaction. The structural and optical properties of thiol-modified TAT-12 LCs were demonstrated by nuclear magnetic resonance (NMR) spectroscopy, ultraviolet-visible (UV-vis) spectroscopy and differential scanning calorimetry (DSC). By one-pot synthesis, thiol-modified TAT-12 LCs were used as the ligands to prepare fluorescent gold nanoclusters ([email protected]) according to the Au-S bond between AuNCs and TAT-12. The spectra of UV-vis absorption and X-ray photoelectron spectroscopy (XPS) of [email protected] indicated that the core of gold of [email protected] exhibited high gold oxidation states. The fluorescence of [email protected] was observed with a maximum intensity at ~352 nm coming from TAT-12 on [email protected] and the fluorescence quantum yield of [email protected] was calculated to be 10.1%. Furthermore, the fluorescence with a maximum intensity at ~448 nm was attributed to a ligand–metal charge transfer between the ligands of TAT-12 LCs and the core of AuNCs. The image of transmission electron microscopy (TEM) further demonstrated an approximately spherical shape of [email protected] with an average size of 2.3 nm. A combination of UV-vis absorption spectra, XPS spectra, fluorescence spectra and TEM image, fluorescent [email protected] were successfully synthesized via one-pot synthesis. Our work provides a practical approach to the synthesis of LCs conjugated AuNCs for future applications in nanobiotechnology. View Full-Text
Keywords: liquid crystals; thiolate ligand; gold nanoclusters; fluorescence; ligand–metal charge transfer; nanobiotechnology liquid crystals; thiolate ligand; gold nanoclusters; fluorescence; ligand–metal charge transfer; nanobiotechnology
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MDPI and ACS Style

Hsu, P.-H.; Yougbaré, S.; Kuo, J.-C.; Krisnawati, D.I.; Jazidie, A.; Nuh, M.; Chou, P.-T.; Hsiao, Y.-C.; Kuo, T.-R. One-Pot Synthesis of Thiol-Modified Liquid Crystals Conjugated Fluorescent Gold Nanoclusters. Nanomaterials 2020, 10, 1755. https://doi.org/10.3390/nano10091755

AMA Style

Hsu P-H, Yougbaré S, Kuo J-C, Krisnawati DI, Jazidie A, Nuh M, Chou P-T, Hsiao Y-C, Kuo T-R. One-Pot Synthesis of Thiol-Modified Liquid Crystals Conjugated Fluorescent Gold Nanoclusters. Nanomaterials. 2020; 10(9):1755. https://doi.org/10.3390/nano10091755

Chicago/Turabian Style

Hsu, Po-Hsuan, Sibidou Yougbaré, Jui-Chi Kuo, Dyah I. Krisnawati, Achmad Jazidie, Mohammad Nuh, Po-Ting Chou, Yu-Cheng Hsiao, and Tsung-Rong Kuo. 2020. "One-Pot Synthesis of Thiol-Modified Liquid Crystals Conjugated Fluorescent Gold Nanoclusters" Nanomaterials 10, no. 9: 1755. https://doi.org/10.3390/nano10091755

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