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Article

Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro

by 1,2,†, 3,†, 3, 1,4,5, 1,2,5, 1,2,6,7, 1,2,4,5,* and 1,3,*
1
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, 119 Dandae-ro, Cheonan 31116, Korea
2
UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea
3
Department of Conservative Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea
4
Department of Biomaterials Science, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea
5
Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine Research Center, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea
6
Division of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, London WC1E 6HH, UK
7
The Discoveries Centre for Regenerative and Precision Medicine, Eastman Dental Institute, University College London, London WC1E 6HH, UK
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nanomaterials 2020, 10(9), 1750; https://doi.org/10.3390/nano10091750
Received: 1 August 2020 / Revised: 29 August 2020 / Accepted: 2 September 2020 / Published: 4 September 2020
(This article belongs to the Special Issue Nanomaterials and Nanotechnology for Regenerative Medicine)
Calcium silicate-based bioactive glass has received significant attention for use in various biomedical applications due to its excellent bioactivity and biocompatibility. However, the bioactivity of calcium silicate nanoparticle-incorporated bioactive dental sealer is not much explored. Herein, three commercially available bioactive root canal sealers (Endoseal MTA (EDS), Well-Root ST (WST), and Nishika Canal Sealer BG (NBG)) were compared with a resin-based control sealer (AH Plus (AHP)) in terms of physical, chemical, and biological properties. EDS and NBG showed 200 to 400 nm and 100 to 200 nm nanoparticle incorporation in the SEM image, respectively, and WST and NBG showed mineral deposition in Hank’s balanced salt solution after 28 days. The flowability and film thickness of all products met the ISO 3107 standard. Water contact angle, linear dimensional changes, and calcium and silicate ion release were significantly different among groups. All bioactive root canal sealers released calcium ions, while NBG released ~10 times more silicon ions than the other bioactive root canal sealers. Under the cytocompatible extraction range, NBG showed prominent cytocompatibility, osteogenecity, and angiogenecity compared to other sealers in vitro. These results indicate that calcium silicate nanoparticle incorporation in dental sealers could be a potential strategy for dental periapical tissue regeneration. View Full-Text
Keywords: root canal sealers; bioactive; osteogenic induction; angiogenic; silicate ions root canal sealers; bioactive; osteogenic induction; angiogenic; silicate ions
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MDPI and ACS Style

Jo, S.B.; Kim, H.K.; Lee, H.N.; Kim, Y.-J.; Dev Patel, K.; Campbell Knowles, J.; Lee, J.-H.; Song, M. Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro. Nanomaterials 2020, 10, 1750. https://doi.org/10.3390/nano10091750

AMA Style

Jo SB, Kim HK, Lee HN, Kim Y-J, Dev Patel K, Campbell Knowles J, Lee J-H, Song M. Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro. Nanomaterials. 2020; 10(9):1750. https://doi.org/10.3390/nano10091750

Chicago/Turabian Style

Jo, Seung Bin, Hyun Kyung Kim, Hae Nim Lee, Yu-Jin Kim, Kapil Dev Patel, Jonathan Campbell Knowles, Jung-Hwan Lee, and Minju Song. 2020. "Physical Properties and Biofunctionalities of Bioactive Root Canal Sealers In Vitro" Nanomaterials 10, no. 9: 1750. https://doi.org/10.3390/nano10091750

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