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Article

Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes

1
Faculty of Photonics and Optical Information, ITMO University, St-Petersburg 197101, Russia
2
School of Chemistry, Trinity College, Dublin, Ireland
3
Institute of Silicate Chemistry of RAS, St-Petersburg 199034, Russia
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(8), 1569; https://doi.org/10.3390/nano10081569
Received: 17 July 2020 / Revised: 30 July 2020 / Accepted: 3 August 2020 / Published: 10 August 2020
(This article belongs to the Special Issue Electronic and Optical Properties of Nanostructures)
Nowadays, multiplex analysis is very popular, since it allows to detect a large number of biomarkers simultaneously. Traditional multiplex analysis is usually based on changes of photoluminescence (PL) intensity and/or PL band spectral positions in the presence of analytes. Using PL lifetime as an additional parameter might increase the efficiency of multiplex methods. Quantum dots (QDs) can be used as luminescent markers for multiplex analysis. Ternary in-based QDs are a great alternative to the traditional Cd-based one. Ternary QDs possess all advantages of traditional QDs, including tunable photoluminescence in visible range. At the same time ternary QDs do not have Cd-toxicity, and moreover they possess long spectral dependent lifetimes. This allows the use of ternary QDs as a donor for time-resolved multiplex sensing based on Förster resonance energy transfer (FRET). In the present work, we implemented FRET from AgInS2/ZnS ternary QDs to cyanine dyes absorbing in different spectral regions of QD luminescence with different lifetimes. As the result, FRET-induced luminescence of dyes differed not only in wavelengths but also in lifetimes of luminescence, which can be used for time-resolved multiplex analysis in biology and medicine. View Full-Text
Keywords: AgInS2; FRET; multiplex analysis; ternary quantum dots; sensing; time-resolved multiplexing; cyanine dyes; nanoparticles AgInS2; FRET; multiplex analysis; ternary quantum dots; sensing; time-resolved multiplexing; cyanine dyes; nanoparticles
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MDPI and ACS Style

Kuznetsova, V.; Tkach, A.; Cherevkov, S.; Sokolova, A.; Gromova, Y.; Osipova, V.; Baranov, M.; Ugolkov, V.; Fedorov, A.; Baranov, A. Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes. Nanomaterials 2020, 10, 1569. https://doi.org/10.3390/nano10081569

AMA Style

Kuznetsova V, Tkach A, Cherevkov S, Sokolova A, Gromova Y, Osipova V, Baranov M, Ugolkov V, Fedorov A, Baranov A. Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes. Nanomaterials. 2020; 10(8):1569. https://doi.org/10.3390/nano10081569

Chicago/Turabian Style

Kuznetsova, Vera, Anton Tkach, Sergei Cherevkov, Anastasiia Sokolova, Yulia Gromova, Viktoria Osipova, Mikhail Baranov, Valery Ugolkov, Anatoly Fedorov, and Alexander Baranov. 2020. "Spectral-Time Multiplexing in FRET Complexes of AgInS2/ZnS Quantum Dot and Organic Dyes" Nanomaterials 10, no. 8: 1569. https://doi.org/10.3390/nano10081569

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