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Review

Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing

1
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore
2
Faculty of Medical Sciences, Krishna Institute of Medical Sciences “Deemed to be University”, Karad, Maharashtra 415539, India
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(6), 1234; https://doi.org/10.3390/nano10061234
Received: 2 June 2020 / Revised: 21 June 2020 / Accepted: 22 June 2020 / Published: 25 June 2020
(This article belongs to the Special Issue Recent Progress in Antimicrobial Nanomaterials)
Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate cellular and cytokines response, infection, poor vascularization, and neuropathy. Effective therapeutic strategies for the management of impaired wound could be attained through a better insight of molecular mechanism and pathophysiology of diabetic wound healing. Nanotherapeutics-based agents engineered within 1–100 nm levels, which include nanoparticles and nanoscaffolds, are recent promising treatment strategies for accelerating diabetic wound healing. Nanoparticles are smaller in size and have high surface area to volume ratio that increases the likelihood of biological interaction and penetration at wound site. They are ideal for topical delivery of drugs in a sustained manner, eliciting cell-to-cell interactions, cell proliferation, vascularization, cell signaling, and elaboration of biomolecules necessary for effective wound healing. Furthermore, nanoparticles have the ability to deliver one or more therapeutic drug molecules, such as growth factors, nucleic acids, antibiotics, and antioxidants, which can be released in a sustained manner within the target tissue. This review focuses on recent approaches in the development of nanoparticle-based therapeutics for enhancing diabetic wound healing. View Full-Text
Keywords: nanoparticle; drug delivery system; diabetes mellitus; wound healing; diabetic foot ulcer; pathophysiology nanoparticle; drug delivery system; diabetes mellitus; wound healing; diabetic foot ulcer; pathophysiology
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MDPI and ACS Style

Ezhilarasu, H.; Vishalli, D.; Dheen, S.T.; Bay, B.-H.; Srinivasan, D.K. Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing. Nanomaterials 2020, 10, 1234. https://doi.org/10.3390/nano10061234

AMA Style

Ezhilarasu H, Vishalli D, Dheen ST, Bay B-H, Srinivasan DK. Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing. Nanomaterials. 2020; 10(6):1234. https://doi.org/10.3390/nano10061234

Chicago/Turabian Style

Ezhilarasu, Hariharan, Dinesh Vishalli, S. T. Dheen, Boon-Huat Bay, and Dinesh K. Srinivasan 2020. "Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing" Nanomaterials 10, no. 6: 1234. https://doi.org/10.3390/nano10061234

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