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Open AccessFeature PaperArticle

Influence of Experimental Parameters of a Continuous Flow Process on the Properties of Very Small Iron Oxide Nanoparticles (VSION) Designed for T1-Weighted Magnetic Resonance Imaging (MRI)

1
Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, B-7000 Mons, Belgium
2
Chimie des Interactions Plasma-Surface (ChIPS), University of Mons, 23 Place du Parc, B-7000 Mons, Belgium
3
Laboratory of Magnetic Fluids, Center for Fundamental and Advanced Technical Research, Romanian Academy—Timisoara Branch, 300223 Timisoara, Romania
4
Research Center for Complex Fluids Systems Engineering, Politehnica University of Timisoara, M. Viteazu Ave. #1, 300222 Timisoara, Romania
5
Center for Microscopy and Molecular Imaging, Rue Adrienne Bolland, 8, B-6041 Gosselies, Belgium
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(4), 757; https://doi.org/10.3390/nano10040757
Received: 12 March 2020 / Revised: 27 March 2020 / Accepted: 30 March 2020 / Published: 15 April 2020
(This article belongs to the Special Issue Applications and Properties of Magnetic Nanoparticles)
This study reports the development of a continuous flow process enabling the synthesis of very small iron oxide nanoparticles (VSION) intended for T1-weighted magnetic resonance imaging (MRI). The influence of parameters, such as the concentration/nature of surfactants, temperature, pressure and the residence time on the thermal decomposition of iron(III) acetylacetonate in organic media was evaluated. As observed by transmission electron microscopy (TEM), the diameter of the resulting nanoparticle remains constant when modifying the residence time. However, significant differences were observed in the magnetic and relaxometric studies. This continuous flow experimental setup allowed the production of VSION with high flow rates (up to 2 mL·min−1), demonstrating the efficacy of such process compared to conventional batch procedure for the scale-up production of VSION. View Full-Text
Keywords: iron oxide nanoparticles; flow synthesis; contrast agents; magnetic resonance imaging iron oxide nanoparticles; flow synthesis; contrast agents; magnetic resonance imaging
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MDPI and ACS Style

Vangijzegem, T.; Stanicki, D.; Panepinto, A.; Socoliuc, V.; Vekas, L.; Muller, R.N.; Laurent, S. Influence of Experimental Parameters of a Continuous Flow Process on the Properties of Very Small Iron Oxide Nanoparticles (VSION) Designed for T1-Weighted Magnetic Resonance Imaging (MRI). Nanomaterials 2020, 10, 757.

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