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Open AccessArticle

Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment

1
CICECO—Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
2
Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(4), 628; https://doi.org/10.3390/nano10040628
Received: 28 February 2020 / Revised: 24 March 2020 / Accepted: 26 March 2020 / Published: 28 March 2020
Nanostructured patches composed of bacterial nanocellulose (BNC), hyaluronic acid (HA) and diclofenac (DCF) were developed, envisioning the treatment of aphthous stomatitis. Freestanding patches were prepared via diffusion of aqueous solutions of HA and DCF, with different concentrations of DCF, into the wet BNC three-dimensional porous network. The resultant dual polysaccharides-based patches with a nanostructured morphology present thermal stability up to 200 °C, as well as good dynamic mechanical properties, with a storage modulus higher than 1.0 GPa. In addition, the patches are non-cytotoxic to human keratinocytes (HaCaT cells), with a cell viability of almost 100% after 24 h. The in vitro release profile of DCF from the patches was evaluated in simulated saliva, and the data refer to a diffusion- and swelling-controlled drug-release mechanism. The attained results hint at the possibility of using these dual polysaccharides-based oral mucosal patches to target aphthous stomatitis. View Full-Text
Keywords: bacterial nanocellulose; hyaluronic acid; diclofenac; nanostructured patches; drug delivery; aphthous stomatitis bacterial nanocellulose; hyaluronic acid; diclofenac; nanostructured patches; drug delivery; aphthous stomatitis
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MDPI and ACS Style

Carvalho, J.P.F.; Silva, A.C.Q.; Bastos, V.; Oliveira, H.; Pinto, R.J.B.; Silvestre, A.J.D.; Vilela, C.; Freire, C.S.R. Nanocellulose-Based Patches Loaded with Hyaluronic Acid and Diclofenac towards Aphthous Stomatitis Treatment. Nanomaterials 2020, 10, 628.

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