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Article

MRI Relaxivity Changes of the Magnetic Nanoparticles Induced by Different Amino Acid Coatings

1
Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Kosice, Slovakia
2
Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
3
Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(2), 394; https://doi.org/10.3390/nano10020394
Received: 30 December 2019 / Revised: 15 February 2020 / Accepted: 18 February 2020 / Published: 24 February 2020
In this study, we analysed the physico-chemical properties of positively charged magnetic fluids consisting of magnetic nanoparticles (MNPs) functionalised by different amino acids (AAs): glycine (Gly), lysine (Lys) and tryptophan (Trp), and the influence of AA–MNP complexes on the MRI relaxivity. We found that the AA coating affects the size of dispersed particles and isoelectric point, as well as the zeta potential of AA–MNPs differently, depending on the AA selected. Moreover, we showed that a change in hydrodynamic diameter results in a change to the relaxivity of AA–MNP complexes. On the one hand, we observed a decrease in the relaxivity values, r1 and r2, with an increase in hydrodynamic diameter (the relaxivity of r1 and r2 were comparable with commercially available contrast agents); on the other hand, we observed an increase in r2* value with an increase in hydrodynamic size. These findings provide an interesting preliminary look at the impact of AA coating on the relaxivity properties of AA–MNP complexes, with a specific application in molecular contrast imaging originating from magnetic nanoparticles and magnetic resonance techniques. View Full-Text
Keywords: magnetic nanoparticles; maghemite; functionalisation; MRI; relaxivity; amino acid; glycine; lysine; tryptophan magnetic nanoparticles; maghemite; functionalisation; MRI; relaxivity; amino acid; glycine; lysine; tryptophan
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MDPI and ACS Style

Antal, I.; Strbak, O.; Khmara, I.; Koneracka, M.; Kubovcikova, M.; Zavisova, V.; Kmetova, M.; Baranovicova, E.; Dobrota, D. MRI Relaxivity Changes of the Magnetic Nanoparticles Induced by Different Amino Acid Coatings. Nanomaterials 2020, 10, 394. https://doi.org/10.3390/nano10020394

AMA Style

Antal I, Strbak O, Khmara I, Koneracka M, Kubovcikova M, Zavisova V, Kmetova M, Baranovicova E, Dobrota D. MRI Relaxivity Changes of the Magnetic Nanoparticles Induced by Different Amino Acid Coatings. Nanomaterials. 2020; 10(2):394. https://doi.org/10.3390/nano10020394

Chicago/Turabian Style

Antal, Iryna, Oliver Strbak, Iryna Khmara, Martina Koneracka, Martina Kubovcikova, Vlasta Zavisova, Martina Kmetova, Eva Baranovicova, and Dusan Dobrota. 2020. "MRI Relaxivity Changes of the Magnetic Nanoparticles Induced by Different Amino Acid Coatings" Nanomaterials 10, no. 2: 394. https://doi.org/10.3390/nano10020394

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