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Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia

1
Institute of Nuclear Chemistry and Technology, Dorodna 16 Str., 03-195 Warsaw, Poland
2
Faculty of Chemistry, University of Warsaw, Pasteura 1 Str., 02-093 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Nanomaterials 2020, 10(2), 288; https://doi.org/10.3390/nano10020288
Received: 30 December 2019 / Revised: 17 January 2020 / Accepted: 4 February 2020 / Published: 8 February 2020
Iron oxide-based nanoparticles have been modified in their core with holmium(III) in an amount affecting only slightly their magnetic properties. Nanoparticles were conjugated covalently with biomolecule of trastuzumab (Herceptin®), the monoclonal antibody that recognizes cancer cells overexpressing HER2 receptors targeting such nanoparticles to the specified tumor tissues. Systematic studies of Ho3+-doped bioconjugates were carried out as a preliminary step for future replacement of ‘cold’ Ho with 166Ho radionuclide, emitting ‘soft’ beta(-) radiation for possible targeted radionuclide therapy. Physicochemical properties of the obtained bioconjugates were subsequently tested for use in magnetic hyperthermia, considered as an effective, low-invasiveness anticancer therapy. With such a system we expect to achieve both: active targeting and multimodal action by simultaneous internal and localized irradiation and magnetic hyperthermia of specific cancers. View Full-Text
Keywords: superparamagnetc iron oxide nanoparticles; SPIONs; trastuzumab; magnetic hyperthermia; antitumor therapy superparamagnetc iron oxide nanoparticles; SPIONs; trastuzumab; magnetic hyperthermia; antitumor therapy
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Gawęda, W.; Osial, M.; Żuk, M.; Pękała, M.; Bilewicz, A.; Krysinski, P. Lanthanide-Doped SPIONs Bioconjugation with Trastuzumab for Potential Multimodal Anticancer Activity and Magnetic Hyperthermia. Nanomaterials 2020, 10, 288.

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