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Open AccessArticle

Bimodal Nd-Doped LuVO4 Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging

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Instituto de Ciencia de Materiales de Sevilla, CSIC-US, Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain
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Departamento de Física de Materiales, C-04, Universidad Autónoma de Madrid, 28049 Madrid, Spain
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Instituto de Ciencia de Materiales de Aragón, CSIC/UniZar and CIBER-BBN, Edificio I+D, Mariano Esquillor s/n, 50018 Zaragoza, Spain
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Centro Nacional de Aceleradores (CNA) (Universidad de Sevilla, Junta de Andalucía, CSIC), c/Thomas Alva Edison 7, Isla de la Cartuja, 41092 Sevilla, Spain
*
Author to whom correspondence should be addressed.
Nanomaterials 2020, 10(1), 149; https://doi.org/10.3390/nano10010149
Received: 12 November 2019 / Revised: 7 January 2020 / Accepted: 7 January 2020 / Published: 14 January 2020
(This article belongs to the Section Synthesis, Interfaces and Nanostructures)
Uniform Nd3+-doped LuVO4 nanophosphors have been synthesized for the first time in literature by using a poliol-based method at 120 °C from Nd3+ and vanadate precursors. After optimizing the Nd doping level, these phosphors present intense luminescence in the near-infrared biological windows. The X-ray attenuation capacity of the optimum nanophosphor has been found to be higher than that of a commercial X-ray computed tomography contrast agent. After surface coating with polyacrylic acid, such nanoparticles present high colloidal stability in physiological pH medium and high cell viability. Because of these properties, the developed Nd3+-doped LuVO4 nanoparticles have potential applications as a bimodal probe for NIR luminescent bioimaging and X-ray computed tomography. View Full-Text
Keywords: nanoparticles; LuVO4; neodymium; polyacrilic acid; NIR luminescence; X-ray computed tomography nanoparticles; LuVO4; neodymium; polyacrilic acid; NIR luminescence; X-ray computed tomography
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MDPI and ACS Style

Nuñez, N.O.; Cussó, F.; Cantelar, E.; Martin-Gracia, B.; de la Fuente, J.M.; Corral, A.; Balcerzyk, M.; Ocaña, M. Bimodal Nd-Doped LuVO4 Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging. Nanomaterials 2020, 10, 149.

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