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Bioactive Glasses: From Parent 45S5 Composition to Scaffold-Assisted Tissue-Healing Therapies
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Bioactive Glasses: Where Are We and Where Are We Going?

1
Institute of Materials Physics and Engineering, Applied Science and Technology Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy
2
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, 14155-6447 Tehran, Iran
3
Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran
4
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, P.O. Box 917794-8564, Mashhad, Iran
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2018, 9(1), 25; https://doi.org/10.3390/jfb9010025
Received: 17 February 2018 / Revised: 11 March 2018 / Accepted: 16 March 2018 / Published: 19 March 2018
(This article belongs to the Special Issue Recent Advances in Bioactive Glasses)
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Abstract

Bioactive glasses caused a revolution in healthcare and paved the way for modern biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by Larry Hench fifty years ago, was able to bond to living bone and to stimulate osteogenesis through the release of biologically-active ions. 45S5-based glass products have been successfully implanted in millions of patients worldwide, mainly to repair bone and dental defects and, over the years, many other bioactive glass compositions have been proposed for innovative biomedical applications, such as soft tissue repair and drug delivery. The full potential of bioactive glasses seems still yet to be fulfilled, and many of today’s achievements were unthinkable when research began. As a result, the research involving bioactive glasses is highly stimulating and requires a cross-disciplinary collaboration among glass chemists, bioengineers, and clinicians. The present article provides a picture of the current clinical applications of bioactive glasses, and depicts six relevant challenges deserving to be tackled in the near future. We hope that this work can be useful to both early-stage researchers, who are moving with their first steps in the world of bioactive glasses, and experienced scientists, to stimulate discussion about future research and discover new applications for glass in medicine. View Full-Text
Keywords: bioglass; tissue engineering; scaffold; coating; angiogenesis; drug delivery; ion release; mesoporous bioactive glasses; in vitro; in vivo bioglass; tissue engineering; scaffold; coating; angiogenesis; drug delivery; ion release; mesoporous bioactive glasses; in vitro; in vivo
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Baino, F.; Hamzehlou, S.; Kargozar, S. Bioactive Glasses: Where Are We and Where Are We Going? J. Funct. Biomater. 2018, 9, 25.

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