Next Article in Journal
Towards Additive Manufacture of Functional, Spline-Based Morphometric Models of Healthy and Diseased Coronary Arteries: In Vitro Proof-of-Concept Using a Porcine Template
Previous Article in Journal
Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications
Open AccessReview

Advances in Degradable Embolic Microspheres: A State of the Art Review

1
School of Biomedical Engineering, Dalhousie University, Halifax, NS B3H 4R2, Canada
2
Department of Applied Oral Sciences, Faculty of Dentistry, 5981 University Avenue, P.O. BOX 15000, Halifax, NS B3H 4R2, Canada
3
ABK Biomedical Inc., Unit 32, 155 Chain Lake Drive, Halifax, NS B3S 1B3, Canada
4
Department of Radiology, Division of Vascular and Interventional Radiology, Fienberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
5
Department of Radiology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
6
Interventional Radiology and Diagnostic Imaging Department, Room 3316, Halifax Infirmary Site, QEII Health Sciences Center, 1796 Summer St, Halifax, NS B3H 3A7, Canada
*
Authors to whom correspondence should be addressed.
J. Funct. Biomater. 2018, 9(1), 14; https://doi.org/10.3390/jfb9010014
Received: 19 December 2017 / Revised: 19 January 2018 / Accepted: 24 January 2018 / Published: 26 January 2018
Considerable efforts have been placed on the development of degradable microspheres for use in transarterial embolization indications. Using the guidance of the U.S. Food and Drug Administration (FDA) special controls document for the preclinical evaluation of vascular embolization devices, this review consolidates all relevant data pertaining to novel degradable microsphere technologies for bland embolization into a single reference. This review emphasizes intended use, chemical composition, degradative mechanisms, and pre-clinical safety, efficacy, and performance, while summarizing the key advantages and disadvantages for each degradable technology that is currently under development for transarterial embolization. This review is intended to provide an inclusive reference for clinicians that may facilitate an understanding of clinical and technical concepts related to this field of interventional radiology. For materials scientists, this review highlights innovative devices and current evaluation methodologies (i.e., preclinical models), and is designed to be instructive in the development of innovative/new technologies and evaluation methodologies. View Full-Text
Keywords: resorbable; bioresorbable; degradable; microsphere; embolization resorbable; bioresorbable; degradable; microsphere; embolization
Show Figures

Graphical abstract

MDPI and ACS Style

Doucet, J.; Kiri, L.; O’Connell, K.; Kehoe, S.; Lewandowski, R.J.; Liu, D.M.; Abraham, R.J.; Boyd, D. Advances in Degradable Embolic Microspheres: A State of the Art Review. J. Funct. Biomater. 2018, 9, 14.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop