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J. Funct. Biomater. 2018, 9(1), 14;

Advances in Degradable Embolic Microspheres: A State of the Art Review

School of Biomedical Engineering, Dalhousie University, Halifax, NS B3H 4R2, Canada
Department of Applied Oral Sciences, Faculty of Dentistry, 5981 University Avenue, P.O. BOX 15000, Halifax, NS B3H 4R2, Canada
ABK Biomedical Inc., Unit 32, 155 Chain Lake Drive, Halifax, NS B3S 1B3, Canada
Department of Radiology, Division of Vascular and Interventional Radiology, Fienberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Department of Radiology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
Interventional Radiology and Diagnostic Imaging Department, Room 3316, Halifax Infirmary Site, QEII Health Sciences Center, 1796 Summer St, Halifax, NS B3H 3A7, Canada
Authors to whom correspondence should be addressed.
Received: 19 December 2017 / Revised: 19 January 2018 / Accepted: 24 January 2018 / Published: 26 January 2018
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Considerable efforts have been placed on the development of degradable microspheres for use in transarterial embolization indications. Using the guidance of the U.S. Food and Drug Administration (FDA) special controls document for the preclinical evaluation of vascular embolization devices, this review consolidates all relevant data pertaining to novel degradable microsphere technologies for bland embolization into a single reference. This review emphasizes intended use, chemical composition, degradative mechanisms, and pre-clinical safety, efficacy, and performance, while summarizing the key advantages and disadvantages for each degradable technology that is currently under development for transarterial embolization. This review is intended to provide an inclusive reference for clinicians that may facilitate an understanding of clinical and technical concepts related to this field of interventional radiology. For materials scientists, this review highlights innovative devices and current evaluation methodologies (i.e., preclinical models), and is designed to be instructive in the development of innovative/new technologies and evaluation methodologies. View Full-Text
Keywords: resorbable; bioresorbable; degradable; microsphere; embolization resorbable; bioresorbable; degradable; microsphere; embolization

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Doucet, J.; Kiri, L.; O’Connell, K.; Kehoe, S.; Lewandowski, R.J.; Liu, D.M.; Abraham, R.J.; Boyd, D. Advances in Degradable Embolic Microspheres: A State of the Art Review. J. Funct. Biomater. 2018, 9, 14.

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