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J. Funct. Biomater. 2017, 8(3), 29;

Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis

Department of Physiology, University Center of Health Sciences ,University of Guadalajara, Guadalajara, Jalisco 44100, Mexico
Department of Clinical Surgery, Fray Antonio Alcalde Hospital, University of Guadalajara, Guadalajara, Jalisco 44100, Mexico
Sophia Laboratories, Guadalajara 45010, Jalisco, México
Author to whom correspondence should be addressed.
Academic Editor: Christine Knabe-Ducheyne
Received: 15 June 2017 / Revised: 30 June 2017 / Accepted: 12 July 2017 / Published: 19 July 2017
(This article belongs to the Special Issue Biodegradable Scaffolds)
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Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis. Patients were evaluated through X-ray images and a millimetric slide over a one year period. The application of CH/HAP produced an average alveolar bone growth of 5.77 mm (±1.87 mm). At the onset of the study, the dental pocket exhibited a depth level (DPDL) of 8.66 mm and decreased to 3.55 mm one year after the implant. Tooth mobility grade was 2.44 mm at the onset and 0.8 mm at the end of the study with a significant difference of p < 0.001. Moreover, the bone density in the affected areas was similar to the density of the bone adjacent to it. This result was confirmed with the software implant viewer from Anne Solutions Company. In conclusion, the CH/HAP implant promoted alveolar bone growth in periodontitis patients. View Full-Text
Keywords: chitosan; hydroxyapatite; periodontitis; guided bone regeneration chitosan; hydroxyapatite; periodontitis; guided bone regeneration

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Vaca-Cornejo, F.; Reyes, H.M.; Jiménez, S.H.D.; Velázquez, R.A.L.; Jiménez, J.M.D. Pilot Study Using a Chitosan-Hydroxyapatite Implant for Guided Alveolar Bone Growth in Patients with Chronic Periodontitis. J. Funct. Biomater. 2017, 8, 29.

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