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Silver-Doped Calcium Phosphate Bone Cements with Antibacterial Properties

Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche, CNR-ISM, Via del Fosso del Cavaliere 100, Rome 00133, Italy
A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Leninsky Prospect 49, Moscow 119334, Russia
Dipartimento di Chimica, Università di Roma “La Sapienza”, Piazzale Aldo Moro 5, Rome 00185, Italy
Kurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Leninsky Prospect 31, Moscow 119991, Russia
Authors to whom correspondence should be addressed.
Academic Editor: James Tsoi
J. Funct. Biomater. 2016, 7(2), 10;
Received: 25 February 2016 / Revised: 12 April 2016 / Accepted: 12 April 2016 / Published: 18 April 2016
(This article belongs to the Collection Biocements for Medical/Dental Purposes)
PDF [5288 KB, uploaded 18 April 2016]


Calcium phosphate bone cements (CPCs) with antibacterial properties are demanded for clinical applications. In this study, we demonstrated the use of a relatively simple processing route based on preparation of silver-doped CPCs (CPCs-Ag) through the preparation of solid dispersed active powder phase. Real-time monitoring of structural transformations and kinetics of several CPCs-Ag formulations (Ag = 0 wt %, 0.6 wt % and 1.0 wt %) was performed by the Energy Dispersive X-ray Diffraction technique. The partial conversion of β-tricalcium phosphate (TCP) phase into the dicalcium phosphate dihydrate (DCPD) took place in all the investigated cement systems. In the pristine cement powders, Ag in its metallic form was found, whereas for CPC-Ag 0.6 wt % and CPC-Ag 1.0 wt % cements, CaAg(PO3)3 was detected and Ag (met.) was no longer present. The CPC-Ag 0 wt % cement exhibited a compressive strength of 6.5 ± 1.0 MPa, whereas for the doped cements (CPC-Ag 0.6 wt % and CPC-Ag 1.0 wt %) the reduced values of the compressive strength 4.0 ± 1.0 and 1.5 ± 1.0 MPa, respectively, were detected. Silver-ion release from CPC-Ag 0.6 wt % and CPC-Ag 1.0 wt % cements, measured by the Atomic Emission Spectroscopy, corresponds to the average values of 25 µg/L and 43 µg/L, respectively, rising a plateau after 15 days. The results of the antibacterial test proved the inhibitory effect towards pathogenic Escherichia coli for both CPC-Ag 0.6 wt % and CPC-Ag 1.0 wt % cements, better performances being observed for the cement with a higher Ag-content. View Full-Text
Keywords: bone cement; calcium phosphate; tricalcium phosphate; silver; CaAg(PO3)3; infection; bone graft bone cement; calcium phosphate; tricalcium phosphate; silver; CaAg(PO3)3; infection; bone graft

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Rau, J.V.; Fosca, M.; Graziani, V.; Egorov, A.A.; Zobkov, Y.V.; Fedotov, A.Y.; Ortenzi, M.; Caminiti, R.; Baranchikov, A.E.; Komlev, V.S. Silver-Doped Calcium Phosphate Bone Cements with Antibacterial Properties. J. Funct. Biomater. 2016, 7, 10.

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