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J. Funct. Biomater. 2015, 6(3), 687-707;

Peptide Amphiphiles in Corneal Tissue Engineering

Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
Author to whom correspondence should be addressed.
Academic Editor: Dimitrios Karamichos
Received: 30 June 2015 / Revised: 29 July 2015 / Accepted: 3 August 2015 / Published: 6 August 2015
(This article belongs to the Special Issue Ocular Tissue Engineering)
Full-Text   |   PDF [4602 KB, uploaded 6 August 2015]   |  


The increasing interest in effort towards creating alternative therapies have led to exciting breakthroughs in the attempt to bio-fabricate and engineer live tissues. This has been particularly evident in the development of new approaches applied to reconstruct corneal tissue. The need for tissue-engineered corneas is largely a response to the shortage of donor tissue and the lack of suitable alternative biological scaffolds preventing the treatment of millions of blind people worldwide. This review is focused on recent developments in corneal tissue engineering, specifically on the use of self-assembling peptide amphiphiles for this purpose. Recently, peptide amphiphiles have generated great interest as therapeutic molecules, both in vitro and in vivo. Here we introduce this rapidly developing field, and examine innovative applications of peptide amphiphiles to create natural bio-prosthetic corneal tissue in vitro. The advantages of peptide amphiphiles over other biomaterials, namely their wide range of functions and applications, versatility, and transferability are also discussed to better understand how these fascinating molecules can help solve current challenges in corneal regeneration. View Full-Text
Keywords: cornea; corneal diseases; peptide amphiphiles; bioactive molecules; tissue engineering; corneal tissue engineering; wound healing cornea; corneal diseases; peptide amphiphiles; bioactive molecules; tissue engineering; corneal tissue engineering; wound healing

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Miotto, M.; Gouveia, R.M.; Connon, C.J. Peptide Amphiphiles in Corneal Tissue Engineering. J. Funct. Biomater. 2015, 6, 687-707.

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