Next Article in Journal
Heat Generation and Transfer Behaviors of Ti-Coated Carbon Steel Rod Adaptable for Ablation Therapy of Oral Cancer
Next Article in Special Issue
Cultivation of Human Microvascular Endothelial Cells on Topographical Substrates to Mimic the Human Corneal Endothelium
Previous Article in Journal
Use of an Ophthalmic Viscosurgical Device for Experimental Retinal Detachment in Rabbit Eyes
Open AccessArticle

Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

1
Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
2
Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
3
Department of Cardiothoracic Surgery, University of Utah, Salt Lake City, UT 84112, USA
4
Department of Mechanical Engineering, University of Utah, Salt Lake City, UT 84112, USA
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2013, 4(1), 14-26; https://doi.org/10.3390/jfb4010014
Received: 1 November 2012 / Revised: 17 December 2012 / Accepted: 11 January 2013 / Published: 18 January 2013
(This article belongs to the Special Issue Advances in Ophthalmic Biomaterials)
The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II®, a polycarbonate urethane. The devices have been optimized using Avastin® as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits. View Full-Text
Keywords: CDR; capsular bag; drug delivery; biocompatibility CDR; capsular bag; drug delivery; biocompatibility
Show Figures

Figure 1

MDPI and ACS Style

Gooch, N.; Burr, R.M.; Holt, D.J.; Gale, B.; Ambati, B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. J. Funct. Biomater. 2013, 4, 14-26. https://doi.org/10.3390/jfb4010014

AMA Style

Gooch N, Burr RM, Holt DJ, Gale B, Ambati B. Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device. Journal of Functional Biomaterials. 2013; 4(1):14-26. https://doi.org/10.3390/jfb4010014

Chicago/Turabian Style

Gooch, Nathan; Burr, Randon M.; Holt, Dolly J.; Gale, Bruce; Ambati, Balamurali. 2013. "Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device" J. Funct. Biomater. 4, no. 1: 14-26. https://doi.org/10.3390/jfb4010014

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop