Tissue-Engineered Models of the Human Brain: State-of-the-Art Analysis and Challenges
Round 1
Reviewer 1 Report
Comments for author File: 
Comments.docx
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
This manuscript, entitled "Tissue engineered models of human brain: state of the art and challenges," is a very comprehensive review article that focuses on brain tissue models that can be used in preclinical studies. It summarizes the topic well enough with the necessary details and needs some minor corrections to be accepted.
The involvement of ECM in organs-on-chip models should be discussed in more detail.
The difficulties of microglial cells in TE brain models should be better explained.
-Bacterial cellulose should be briefly mentioned in TE models.
-Figures 4, 5, and 6 are not cited in the text.
-Some minor wording errors:
The phrase "thanks to" is used a lot.
Decellularised should be corrected.
the pons and cros of immunotherapy and the use of Chinese medicine in combination with chemotherapy to overcome the problems of immune checkpoint blockers. The review article can be accepted after some minor corrections.
The title could be changed to focus more on Chinese medicine with ICBs.
In the sentence 'Moreover, as cancer cells can readily switch to the "aerobic glycolysis" cycle even in the presence of oxygen (unlike normal cells), it would be futile to "starve" cancer cells by glucose deprivation...' aerobic should be corrected to anaerobic.
The paragraph should be reviewed that begins 'Recently, for hepatocellular cancer (HCC, an aggressive cancer), an anti-VEGF agent (bevacizumab 15 mg/kg) was added to atezolizumab (an ICB) to achieve higher...'. Some parts are missing in the second and third sentences.
The text should be carefully checked and corrected because there are many wording and grammatical errors throughout the text.
Author Response
Please see the attachment.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
The text reads much better. Please correct a remaining typo (GC / GT) in the section Authors' contribution and throughout the ms. I accept the publication of the ms in the present form after this.
