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Article

Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO3 and Demineralized Bone Matrix

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Research Group GIBEC, Life Sciences Faculty, EIA University, Envigado 055420, Colombia
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Research and Innovation Group in Chemical Formulations, Life Sciences Faculty, EIA University, Envigado 055420, Colombia
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CECOLTEC, Medellín 050022, Colombia
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Author to whom correspondence should be addressed.
Academic Editors: Adriana Bigi and Ebrahim Mostafavi
J. Funct. Biomater. 2021, 12(3), 46; https://doi.org/10.3390/jfb12030046
Received: 17 June 2021 / Revised: 30 July 2021 / Accepted: 4 August 2021 / Published: 11 August 2021
The occurrence of bone-related disorders and diseases has dramatically increased in recent years around the world. Demineralized bone matrix (DBM) has been widely used as a bone implant due to its osteoinduction and bioactivity. However, the use of DBM is limited because it is a particulate material, which makes it difficult to manipulate and implant with precision. In addition, these particles are susceptible to migration to other sites. To address this situation, DBM is commonly incorporated into a variety of carriers. An injectable scaffold has advantages over bone grafts or preformed scaffolds, such as the ability to flow and fill a bone defect. The aim of this research was to develop a DBM carrier with such viscoelastic properties in order to obtain an injectable bone substitute (IBS). The developed DBM carrier consisted of a PVA/glycerol network cross-linked with borax and reinforced with CaCO3 as a pH neutralizer, porosity generator, and source of Ca. The physicochemical properties were determined by an injectability test, FTIR, SEM, and TGA. Porosity, degradation, bioactivity, possible cytotoxic effect, and proliferation in osteoblasts were also determined. The results showed that the developed material has great potential to be used in bone tissue regeneration. View Full-Text
Keywords: bone tissue regeneration; injectable; bone graft; fracture; osteoblast; bone tissue engineering bone tissue regeneration; injectable; bone graft; fracture; osteoblast; bone tissue engineering
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MDPI and ACS Style

Medrano-David, D.; Lopera, A.M.; Londoño, M.E.; Araque-Marín, P. Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO3 and Demineralized Bone Matrix. J. Funct. Biomater. 2021, 12, 46. https://doi.org/10.3390/jfb12030046

AMA Style

Medrano-David D, Lopera AM, Londoño ME, Araque-Marín P. Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO3 and Demineralized Bone Matrix. Journal of Functional Biomaterials. 2021; 12(3):46. https://doi.org/10.3390/jfb12030046

Chicago/Turabian Style

Medrano-David, Daniela, Aura María Lopera, Martha Elena Londoño, and Pedronel Araque-Marín. 2021. "Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO3 and Demineralized Bone Matrix" Journal of Functional Biomaterials 12, no. 3: 46. https://doi.org/10.3390/jfb12030046

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