Next Article in Journal
Engineering-Based Thermal CFD Simulations on Massive Parallel Systems
Previous Article in Journal
Simulation Frameworks for Morphogenetic Problems
Previous Article in Special Issue
Coupling of Petri Net Models of the Mycobacterial Infection Process and Innate Immune Response
Article Menu

Export Article

Open AccessCommunication
Computation 2015, 3(2), 222-234;

Computational Approach to 3D Modeling of the Lymph Node Geometry

Lomonosov Moscow State University, Lenenskie Gori 1, Moscow 119991, Russia
Institute of Immunobiology, Kantonsspital St. Gallen, St. Gallen 9007, Switzerland
Institute of Numerical Mathematics, Russian Academy of Sciences, Gubkina 8, Moscow 119333, Russia
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Filippo Castiglione and Paolo Tieri
Received: 16 January 2015 / Revised: 3 May 2015 / Accepted: 8 May 2015 / Published: 22 May 2015
(This article belongs to the Special Issue Computational Studies of Immune System Function)
Full-Text   |   PDF [3209 KB, uploaded 3 June 2015]   |  


In this study we present a computational approach to the generation of the major geometric structures of an idealized murine lymph node (LN). In this generation, we consider the major compartments such as the subcapsular sinus, B cell follicles, trabecular and medullar sinuses, blood vessels and the T cell zone with a primary focus on the fibroblastic reticular cell (FRC) network. Confocal microscopy data of LN macroscopic structures and structural properties of the FRC network have been generated and utilized in the present model. The methodology sets a library of modules that can be used to assemble a solid geometric LN model and subsequently generate an adaptive mesh model capable of implementing transport phenomena. Overall, based on the use of high-resolution confocal microscopy and morphological analysis of cell 3D reconstructions, we have developed a computational model of the LN geometry, suitable for further investigation in studies of fluid transport and cell migration in this immunologically essential organ. View Full-Text
Keywords: lymph node; FRC network; geometric model; computational method lymph node; FRC network; geometric model; computational method

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Kislitsyn, A.; Savinkov, R.; Novkovic, M.; Onder, L.; Bocharov, G. Computational Approach to 3D Modeling of the Lymph Node Geometry. Computation 2015, 3, 222-234.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Computation EISSN 2079-3197 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top