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Computation 2015, 3(2), 150-176;

Coupling of Petri Net Models of the Mycobacterial Infection Process and Innate Immune Response

Leiden Institute of Advanced Computer Science, Leiden University, Niels Bohrweg 1, 2333CA Leiden, The Netherlands
Author to whom correspondence should be addressed.
Academic Editors: Filippo Castiglione and Paolo Tieri
Received: 23 January 2015 / Revised: 19 March 2015 / Accepted: 26 March 2015 / Published: 8 April 2015
(This article belongs to the Special Issue Computational Studies of Immune System Function)
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Computational and mathematical modeling is important in support of a better understanding of complex behavior in biology. For the investigation of biological systems, researchers have used computers to construct, verify, and validate models that describe the mechanisms behind biological processes in multi-scale representations. In this paper we combine Petri net models that represent the mycobacterial infection process and innate immune response at various levels of organization, from molecular interaction to granuloma dissemination. In addition to the conventional graphical representation of the Petri net, the outcome of the model is projected onto a 3D model representing the zebrafish embryo. In this manner we provide a visualization of the process in a simulation framework that portrays the infection in the living system. View Full-Text
Keywords: immune system modeling; petri net; 3D visualization immune system modeling; petri net; 3D visualization

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Carvalho, R.V.; van den Heuvel, J.; Kleijn, J.; Verbeek, F.J. Coupling of Petri Net Models of the Mycobacterial Infection Process and Innate Immune Response. Computation 2015, 3, 150-176.

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