Next Article in Journal / Special Issue
Comparative Performance Evaluation of an Accuracy-Enhancing Lyapunov Solver
Previous Article in Journal / Special Issue
Optimal Resource Allocation to Reduce an Epidemic Spread and Its Complication
Open AccessArticle

Optimal Control of Virus Spread under Different Conditions of Resources Limitations

Department of Computer Control and Management Engineering Antonio Ruberti, Sapienza University of Rome, via Ariosto 25, 00185 Rome, Italy
Author to whom correspondence should be addressed.
2018 22nd International Conference on System Theory, Control and Computing (ICSTCC), Sinaia, Romania, 10–12 October 2018.
Information 2019, 10(6), 214;
Received: 30 April 2019 / Revised: 13 June 2019 / Accepted: 18 June 2019 / Published: 19 June 2019
(This article belongs to the Special Issue ICSTCC 2018: Advances in Control and Computers)
The paper addresses the problem of human virus spread reduction when the resources for the control actions are somehow limited. This kind of problem can be successfully solved in the framework of the optimal control theory, where the best solution, which minimizes a cost function while satisfying input constraints, can be provided. The problem is formulated in this contest for the case of the HIV/AIDS virus, making use of a model that considers two classes of susceptible subjects, the wise people and the people with incautious behaviours, and three classes of infected, the ones still not aware of their status, the pre-AIDS patients and the AIDS ones; the control actions are represented by an information campaign, to reduce the category of subjects with unwise behaviour, a test campaign, to reduce the number of subjects not aware of having the virus, and the medication on patients with a positive diagnosis. The cost function considered aims at reducing patients with positive diagnosis using as less resources as possible. Four different types of resources bounds are considered, divided into two classes: limitations on the instantaneous control and fixed total budgets. The optimal solutions are numerically computed, and the results of simulations performed are illustrated and compared to put in evidence the different behaviours of the control actions. View Full-Text
Keywords: virus spread; HIV/AIDS infection; optimal control; resource limitations virus spread; HIV/AIDS infection; optimal control; resource limitations
Show Figures

Figure 1

MDPI and ACS Style

Di Giamberardino, P.; Iacoviello, D. Optimal Control of Virus Spread under Different Conditions of Resources Limitations. Information 2019, 10, 214.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

Back to TopTop