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Challenges 2019, 10(1), 23;

Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic Disease

Telethon Kids Institute; University of Western Australia, Nedlands, WA 6009, Australia
Department of Pediatrics, Division of Infectious Diseases, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
Authors to whom correspondence should be addressed.
Received: 14 December 2018 / Revised: 8 March 2019 / Accepted: 13 March 2019 / Published: 21 March 2019
PDF [636 KB, uploaded 21 March 2019]
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Modernization has now been linked to poor developmental experience, the onset of immune dysregulation and rising rates of chronic diseases in many parts of the world. Research across the epidemiological, clinical, and basic science domains supports the concept that poor developmental experience, particularly during prenatal life, can increase the risk of chronic disease, with enduring effects on long-term health. Single ‘omics’ approaches are ill-suited to dealing with the level of complexity that underpins immune dysregulation in early life. A more comprehensive systems-level view is afforded by combining multiple ‘omics’ datasets in order to delineate correlations across multiple resolutions of the genome, and of the genomes of the microorganisms that inhabit us. In this concept paper, we discuss multiomic approaches to studying immune dysregulation and highlight some of the challenges and opportunities afforded by this new domain of medical science. View Full-Text
Keywords: multiomics; dysregulation; immune system; development; modernity multiomics; dysregulation; immune system; development; modernity

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Martino, D.; Ben-Othman, R.; Harbeson, D.; Bosco, A. Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic Disease. Challenges 2019, 10, 23.

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