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Review

Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis

1
Institute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary
2
János Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary
3
Centre for Translational Medicine, Department of Medicine, University of Szeged, 6725 Szeged, Hungary
4
Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary
5
Heim Pál Children’s Hospital, 1089 Budapest, Hungary
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(9), 2698; https://doi.org/10.3390/jcm9092698
Received: 3 July 2020 / Revised: 10 August 2020 / Accepted: 18 August 2020 / Published: 20 August 2020
The prevalence of fatty liver disease (FLD) and that of non-alcoholic fatty liver disease (NAFLD) share some risk factors known to exacerbate the course of acute pancreatitis (AP). This meta-analysis aimed to investigate whether FLD or NAFLD carry a higher risk of untoward outcomes in AP. In accordance with PRISMA guidelines, we performed a systematic search in seven medical databases for cohort studies that compared the outcomes of AP for the presence of FLD or NAFLD, and we calculated pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI). We included 13 articles in our meta-analysis. AP patients with FLD were more likely to die (5.09% vs 1.89%, OR = 3.56, CI = 1.75–7.22), develop severe AP (16.33% vs 7.87%, OR = 2.67, CI = 2.01–3.56), necrotizing pancreatitis (34.83% vs 15.75%, OR = 3.08, CI = 2.44–3.90) and had longer in-hospital stay (10.8 vs 9.2 days, WMD = 1.46, OR = 0.54–2.39). Patients with NAFLD were more likely to have severe AP and longer hospital stay. Both FLD and NAFLD proved to be independent risk factors of a more severe disease course (OR = 3.68, CI = 2.16–6.29 and OR = 3.39, CI = 1.52–7.56 for moderate/ severe vs. mild AP, respectively). FLD and NAFLD worsen the outcomes of AP, which suggests that incorporating FLD or NAFLD into prognostic scoring systems of AP outcomes might improve the prediction of severity and contribute to a more individualized patient care. View Full-Text
Keywords: acute pancreatitis; fatty liver disease; non-alcoholic fatty liver disease; hepatology; pancreatology; prognosis acute pancreatitis; fatty liver disease; non-alcoholic fatty liver disease; hepatology; pancreatology; prognosis
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MDPI and ACS Style

Váncsa, S.; Németh, D.; Hegyi, P.; Szakács, Z.; Hegyi, P.J.; Pécsi, D.; Mikó, A.; Erőss, B.; Erős, A.; Pár, G. Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis. J. Clin. Med. 2020, 9, 2698. https://doi.org/10.3390/jcm9092698

AMA Style

Váncsa S, Németh D, Hegyi P, Szakács Z, Hegyi PJ, Pécsi D, Mikó A, Erőss B, Erős A, Pár G. Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine. 2020; 9(9):2698. https://doi.org/10.3390/jcm9092698

Chicago/Turabian Style

Váncsa, Szilárd, Dávid Németh, Péter Hegyi, Zsolt Szakács, Péter J. Hegyi, Dániel Pécsi, Alexandra Mikó, Bálint Erőss, Adrienn Erős, and Gabriella Pár. 2020. "Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis: A Systematic Review and Meta-Analysis" Journal of Clinical Medicine 9, no. 9: 2698. https://doi.org/10.3390/jcm9092698

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