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Article

Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease

1
Department of Internal Medicine, Division of Gastroenterology and Hepatology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461, Japan
2
Department of Internal Medicine, Division of Gastroenterology, Fuji City General Hospital, 50 Takashima-cho, Fuji-shi, Shizuoka 417-8567, Japan
3
Department of Rehabilitation Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461, Japan
4
Core Research Facilities, Research Center for Medical Science, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461, Japan
*
Authors to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(8), 2381; https://doi.org/10.3390/jcm9082381
Received: 15 June 2020 / Revised: 19 July 2020 / Accepted: 24 July 2020 / Published: 26 July 2020
(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Osteosarcopenia and frailty have a negative health impact on an aging society. This cross-sectional study aimed to investigate the clinical characteristics and relationship of osteosarcopenia and frailty in 291 patients with chronic liver disease (CLD), who comprised 137 males and 154 females, with a median age of 70.0 years. Sarcopenia was diagnosed according to the Japan Society of Hepatology criteria. Bone mineral density was measured using dual-energy X-ray absorptiometry. Frailty was defined by five parameters (exhaustion, slowness, weakness, low physical activity, and weight loss). Among the 291 patients, 49 (16.8%) and 81 (27.8%) had osteosarcopenia and frailty, respectively. Frailty and vertebral fracture were more frequently noted in patients with osteosarcopenia than in those without osteosarcopenia (79.6% vs. 17.4% and 59.2% vs. 20.2%, respectively; p < 0.001 for both). Meanwhile, osteosarcopenia and vertebral fracture were more frequently observed in patients with frailty than in those without frailty (48.1% vs. 4.8% and 49.4% vs. 18.1%, respectively; p < 0.001 for both). On multivariate analysis, frailty was an independent factor associated with osteosarcopenia (odds ratio (OR), 9.837; p < 0.001), and vice versa (OR, 10.069; p < 0.001). Osteosarcopenia and frailty were prevalent, closely interrelated, and increased the risk of vertebral fracture in patients with CLD. View Full-Text
Keywords: chronic liver disease; osteosarcopenia; frailty; vertebral fracture chronic liver disease; osteosarcopenia; frailty; vertebral fracture
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MDPI and ACS Style

Saeki, C.; Kanai, T.; Nakano, M.; Oikawa, T.; Torisu, Y.; Abo, M.; Saruta, M.; Tsubota, A. Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease. J. Clin. Med. 2020, 9, 2381. https://doi.org/10.3390/jcm9082381

AMA Style

Saeki C, Kanai T, Nakano M, Oikawa T, Torisu Y, Abo M, Saruta M, Tsubota A. Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease. Journal of Clinical Medicine. 2020; 9(8):2381. https://doi.org/10.3390/jcm9082381

Chicago/Turabian Style

Saeki, Chisato, Tomoya Kanai, Masanori Nakano, Tsunekazu Oikawa, Yuichi Torisu, Masahiro Abo, Masayuki Saruta, and Akihito Tsubota. 2020. "Relationship between Osteosarcopenia and Frailty in Patients with Chronic Liver Disease" Journal of Clinical Medicine 9, no. 8: 2381. https://doi.org/10.3390/jcm9082381

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